Banca de QUALIFICAÇÃO: LUANDERSON CARDOSO PEREIRA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : LUANDERSON CARDOSO PEREIRA
DATE: 14/12/2023
TIME: 09:00
LOCAL: GOOGLE MEET. https://meet.google.com/awf-quzs-jkc
TITLE:

Insecticidal activity of fluralaner (Exzolt®) administered in chickens against triatomines

KEY WORDS:

Chagas disease, fluralaner (Exzolt  ), systemic insecticide, Triatoma,
Rhodnius, chicken

PAGES: 69
BIG AREA: Ciências Biológicas
AREA: Parasitologia
SUMMARY:

Triatoma infestans, Triatoma brasiliensis, Triatoma pseudomaculata and Rhodnius prolixus are vectors of
Trypanosoma cruzi (T. cruzi), etiological agent of Chagas disease, and chickens are important blood food source to
triatomines. The aim of this study was to evaluate the insecticidal activity of fluralaner (Exzolt  ) administrated in
chickens against triatomines (R. prolixus, T. infestans, T. brasiliensis and T. pseudomaculata). Twelve non-breed
chickens (Gallus gallus domesticus) (n=12) were randomized according to weight into three groups, Group 1: negative
control (n=4), Group 2: single dose 0.5 mg/kg fluralaner (Exzolt  ) (n=4), Group 3: two doses 0.5 mg/kg fluralaner
(Exzolt  ) (n=4). To carry out the experiment, nymphs of 3 rd , 4 th and 5 th instars of Rhodnius prolixus, Triatoma infestans,
Triatoma brasiliensis and Triatoma pseudomaculata (n=10) were allowed to feed on chickens before treatment, and
1, 7, 14, 21, 28, 35 and 56 days after treatment and insect mortality determined. After the blood meal, feeding
efficiency and mortality of triatomine nymphs were determined. The results demonstrate higher feeding success for
R. prolixus, followed by T. infestans, T. brasiliensis and T. pseudomaculata, respectively. Treatment of chickens with
fluralaner does not affect the blood feeding rate of triatomines. Treatment with two doses of fluralaner showed

higher insecticidal efficacy for R. prolixus, T. infestans and T. brasiliensis, compared to treatment with single dose.
Similar insecticidal efficacy was observed for T. pseudomaculata using treatment with one or two doses of fluralaner.
Insecticidal activity of fluralaner (Exzolt  ) against triatomine bugs was observed up to 21 and 28 days after treatment
with one and two doses of fluralaner, respectively. Together, our results demonstrate that chicken’s treatment with
fluralaner (Exzolt  ) induces insecticidal activity against triatomines up to 28 days after treatment and could be used as
a control measure for Chagas disease in endemic areas.

COMMITTEE MEMBERS:
Externo à Instituição - IVO SANTANA CALDAS - UNIFAL-MG
Externa ao Programa - ***.295.184-** - ANDRESSA NORONHA BARBOSA DA SILVA - UFRN
Presidente - 1752367 - PAULO MARCOS DA MATTA GUEDES