Banca de DEFESA: RAYANE FRANÇA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RAYANE FRANÇA DA SILVA
DATE: 25/08/2022
TIME: 14:00
LOCAL: Sala da Pós-graduação
TITLE:

IMPACT OF THE COVID-19 PANDEMIC ON THE PROFILE OF BACTERIAL RESISTANCE IN A HOSPITAL IN THE CITY OF NATAL-RN

KEY WORDS:

Antibiotics; Covid-19; Health-related infection; Bacterial resistance; Coinfection; Multi-resistance.

PAGES: 58
BIG AREA: Ciências Biológicas
AREA: Microbiologia
SUMMARY:

The emergency of Covid-19 brought an uncertain epidemiological and sanitary scenario, resulting in an increase in the use of antimicrobials in an empirical way to prevent possible bacterial infections acquired secondary to viral infection in patients hospitalized in ICUs. This study aims to evaluate the impact of the Covid-19 pandemic on the bacterial resistance profile in a private hospital located in the city of Natal-RN. This is a cross-sectional descriptive study of a retrospective nature, in which the resistance profile of bacterial isolates from hospitalized patients was evaluated over a period of three years, covering pre-pandemic and pandemic periods. Through the notification sheets of the Hospital Infection Control Service (SCIH) of the hospital studied, 4,330 (92.3%) positive cultures for bacteria were found in the three years evaluated. Bacterial isolates were equally distributed between female and male patients, with a higher prevalence in blood cultures (31%) and urine cultures (29.3%) and from ICUs (43.2%). Patients with Covid-19 had 12.1% bacterial coinfection. The most prevalent bacteria were Gram negative Klebsiella spp. (26.5%), Pseudomonas spp. (22.4%) and Escherichia coli (11.6%). Among the Gram positive, Staphylococcus spp. were the most prevalent (27.1%). Multi-resistance was observed in 2,767 (63%) of the bacteria with the following prevalence: Acinetobacter spp. 110 (86.8%), Pseudomonas spp. 679 (69.9%), Staphylococcus spp. 960 (81.8%) and Klebsiella spp. 692 (60.1%). There was a statistically significant association (p<0.001) of multidrug resistance with the period of the pandemic (2020-2021) as well as with patients diagnosed with COVID-19 (p=0.001). These results show that COVID-19 may imply a possible increase in the circulation of more resistant bacterial strains in the hospital studied in the years that follow, if more specific control measures are not taken.

COMMITTEE MEMBERS:
Externo à Instituição - CAIO AUGUSTO MARTINS AIRES - UFERSA
Interno - 348473 - JOSE VERISSIMO FERNANDES
Presidente - 1452833 - MARIA CELESTE NUNES DE MELO