Banca de QUALIFICAÇÃO: PEDRO HENRIQUE FERREIRA CAVALCANTI

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : PEDRO HENRIQUE FERREIRA CAVALCANTI
DATA : 10/01/2019
HORA: 14:00
LOCAL: A definir
TÍTULO:

Genetic Characterization and Phylogeny of HIV-1 in Rio Grande do Norte

PALAVRAS-CHAVES:

HIV, Resistance mutation, Rio Grande do Norte, Phylogeny.

PÁGINAS: 120
GRANDE ÁREA: Ciências Biológicas
ÁREA: Microbiologia
SUBÁREA: Biologia e Fisiologia dos Microorganismos
ESPECIALIDADE: Virologia
RESUMO:

HIV infection is the cause of the Acquired Immunodeficiency Syndrome (Acquired Immunodeficiency Syndrome), from the earliest reports of the disease in the 1980s to the present day, the virus has claimed approximately 35 million lives and is considered one of the worst pandemics ever recorded in the human species. HIV is an RNA virus belonging to the family Retroviridae, subfamily Orthoretrovirinae of the genus Lentivirus. Although there are two species of HIV, only HIV-1 has a pandemic distribution. Phylogenetically the virus is divided into several groups, subtypes, sub-types, CRF's and URF's. With the advent of highly active antiretroviral therapy (HAART) HIV infection is considered to be chronic, the well treated individual is not developing AIDS, resulting in an improvement in the quality of life, increased survival and the possibility of non-transmissibility. However, increasing resistance to antiretroviral drugs, mainly due to poor adherence to treatment, could jeopardize the global progress made so far in combating HIV. The objective of this study was the genetic characterization and phylogeny of circulating HIV-1 in the State of Rio Grande do Norte from January to October 2018. A total of 5 samples met the criteria established in the research, the phylogeny by means of sequencing of the protease and reverse transcriptase region of the Pol gene, showed a predominance of circulating HIV-1-B with a patient presenting the F1 subtype, analysis of the genetic sequencing of the viruses indicated the presence of several resistance mutations both transmitted and acquired beyond accessory mutations, only 1 mutations of clinical importance were not detected. In conclusion, this study revealed a predominance of circulating HIV-1 subtype B and the mutation profile revealed that the most impaired antiretrovirals were reverse transcriptase inhibitors. The information is fundamental for adequate redirection of therapeutic rescue of these patients and molecular epidemiological screening of circulating strains.

MEMBROS DA BANCA:
Interno - 1346635 - JANEUSA TRINDADE DE SOUTO
Presidente - 1715230 - JOSELIO MARIA GALVAO DE ARAUJO
Externo ao Programa - 1645299 - MARISE REIS DE FREITAS