Banca de DEFESA: ADRIANO CARLOS DE SOUZA JUNIOR

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ADRIANO CARLOS DE SOUZA JUNIOR
DATE: 30/06/2025
TIME: 14:30
LOCAL: Sessão pública realizada por meio de videoconferência
TITLE:

ASSESSMENT OF CARDIOMETABOLIC RISK FACTORS AND METABOLOMIC PROFILE OF PARTICIPANTS IN THE BRAZUCA NATAL COHORT STUDY

KEY WORDS:

Cardiometabolic risk. Metabolomics. Nuclear Magnetic Resonance

PAGES: 75
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Cardiometabolic risk factors include conditions such as obesity, insulin resistance, high blood pressure, dyslipidemia, and type 2 diabetes. These conditions are interconnected by pathophysiological mechanisms such as systemic inflammation, endothelial dysfunction, and oxidative stress. Therefore, the early identification of these changes aims to promote preventive actions. In this regard, advances in the field of omics sciences, including the study of metabolomics, emerge as one of the most important tools to identify possible biomarkers related to cardiometabolic risk factors. Thus, the objectives of this study were to assess the cardiometabolic risk factors and the metabolomic profile by nuclear magnetic resonance (1H-NMR) of adult and elderly individuals participating in the Brazuca Study - Natal during the periods 2019–2020 and 2023–2024. This is a prospective cohort, in which data collection occurred at two moments: pre COVID-19 pandemic (2019–2020) and post pandemic (2023–2024). In both phases of the study, data collection was conducted at the participants' homes, using a questionnaire to obtain sociobiodemographic and lifestyle data, as well as anthropometric and blood pressure measurements. Blood samples were collected to assess markers of lipid, glycemic, and inflammatory profiles. The metabolomic profiles in plasma were assessed using . The study revealed significant changes in sociobiodemographic variables and comorbidities after the COVID-19 pandemic. A significant increase was observed in the number of people who stopped consuming alcoholic beverages and a reduction in frequent consumption (p = 0.046). There was an increase in people with type 2 diabetes (p < 0.001), as well as those with heart disease (p < 0.001). There was a significant increase in cardiovascular risk assessed by the waist-to-height ratio (WHtR) and the visceral adiposity index (VAI) between the pre- and post-pandemic periods (p < 0.001). Additionally, the proportion of participants with altered fasting glucose and HDL-c cholesterol increased significantly in the second phase of the study (p = 0.001 and p = 0.004, respectively). We also found an increase in the percentage of participants with high-sensitivity C-reactive protein (hs-CRP) values classified as low risk in the second phase of the study compared to the first (p < 0.001). Regarding the metabolomic data, the ¹H NMR spectra indicated that the fatty acids from the terminal –CH₃ group (0.83 ppm), acetate (1.92 ppm), glucose (5.23 ppm), and tyrosine (7.20 ppm) were among the most relevant metabolites for distinguishing between the pre- and post-COVID-19 groups. Among the differential metabolites, it is worth noting that glucose levels were higher in the post-COVID-19 group. In contrast, amino acids such as isoleucine and valine, as well as lactate, showed a decrease in the second phase of the study. Therefore, the results suggest changes in cardiometabolic risk factors and in the individuals' metabolomic profiles, with an emphasis on metabolites related to the risk of cardiometabolic diseases.

COMMITTEE MEMBERS:
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Externa ao Programa - 1569526 - RENATA MENDONÇA ARAUJO - UFRNExterno à Instituição - ALEXANDRE COELHO SERQUIZ - UFPB
Externa à Instituição - LJUBICA TASIC - UNICAMP