Banca de QUALIFICAÇÃO: RAYANE FELIPE DE FRANCA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RAYANE FELIPE DE FRANCA
DATE: 26/09/2024
TIME: 14:00
LOCAL: Sessão pública realizada por videoconferência
TITLE:

Evaluation of the impact of ultra-processed food consumption on the antioxidant profile of breast milk

KEY WORDS:

Food consumption. New classification. Endogenous antioxidants. Alpha-tocopherol. Lactation. Breastfeeding.

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Ultra-processed foods (UPF) tend to have a high oxidative capacity, contributing to the triggering of inflammatory processes and the emergence of related diseases. However, the impact of maternal consumption of UPF on the antioxidant components of breast milk is still unknown, since breastfeeding is essential for the healthy development of the baby, providing growth and nutritional factors and a powerful antioxidant capacity via breast milk. The aim was therefore to investigate the relationship between PSA consumption and the antioxidant capacity of breast milk. The study participants were 134 lactating women attending primary health care centers in the municipality of Natal-RN, with a median of 67 days postpartum. The study was approved by the UFRN Research Ethics Committee (CAAE 29928420.7.0000.5292). Socioeconomic and health information was collected, as well as anthropometric measurements, 24-hour recall (R24h) adapted for Nova classification and breast milk extraction by milking one breast. To determine the antioxidant activity of breast milk, the antioxidant enzymes Superoxide dismutase (SOD) and Catalase were analyzed using commercial kits by plate reading, as well as the quantification of alpha-tocopherol by Ultra Performance Liquid Chromatography (UPLC). The theoretical estimate of the supply of vitamin E via breast milk (mg of vitamin E in 780 mL of day) was also evaluated. Dietary intake was assessed according to the caloric intake of UPF in the diet (New Classification) and dietary intake of vitamin E (mg/day). The lactating women had a mean age of 28.1 (standard deviation 6.6) years, were black/brown/indigenous and 51.5% were below the poverty line. In addition, 52.2% had weight retention after childbirth and the majority were overweight before and after childbirth. 63.4% practiced exclusive breastfeeding. As for the antioxidant profile variables, the median concentration of alpha-tocopherol was 187.6 (Interquartile range 116.8-278.2) μg/dL and 54.5% did not theoretically meet the adequate intake of vitamin E for infants (4 mg/day). The SOD enzyme obtained a mean of 2819.4 (standard deviation 889.4) U/mL and Catalase a median of 899.5 (interquartile range 573.7-1847.0) nmol/min/mL. Regarding dietary intake, there was an average of 2,686 calories/day, 23% of which were from UPF, the second largest category consumed. The median intake of dietary vitamin E was 12.3 (interquartile range 7.1-19.6) mg/day, with 60.3% inadequate. For the defense, data on total dietary antioxidant capacity (CATd) will be included and lactating women will be grouped according to tertiles of energy intake of UPF in the diet (tertile 1-2 and tertile 3). Regression equations will be performed to assess the association between the share of PUFA in the diet and antioxidant profile outcomes (alpha-tocopherol, SOD, Catalase, dietary vitamin E and CATd). So far, the data show that the women are socioeconomically vulnerable and have important factors that predispose them to oxidative stress, such as being overweight, low vitamin E intake and low estimates of vitamin E in milk. The other analyses are intended to contribute to knowledge about the impact of UPF consumption on antioxidant capacity during lactation, since oxidative stress can lead to the onset and worsening of chronic non-communicable diseases.

COMMITTEE MEMBERS:
Interna - 2646462 - BRUNA LEAL LIMA MACIEL
Interna - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Presidente - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES