Banca de QUALIFICAÇÃO: NICOLLE CAROLINE SEABRA DOS SANTOS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : NICOLLE CAROLINE SEABRA DOS SANTOS
DATE: 26/11/2025
TIME: 09:00
LOCAL: Sessão pública realizada por meio de Videoconferência
TITLE:

CLINICAL, NUTRITIONAL AND METABOLOMIC PROFILE OF INDIVIDUALS WITH PRESERVED AND REDUCED HEART FAILURE TREATED ON AN OUTPATIENT BASIS

KEY WORDS:

Heart Failure. Cardiac Metabolism. Diet. Metabolomics. Nutrimetabolomics. ¹H-NMR.

PAGES: 78
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Heart failure (HF) is a complex clinical syndrome that can be classified into two main phenotypes: HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), each with distinct characteristics and treatment. Nutrimetabolomics allows the investigation of the interaction between diet and metabolism, contributing to the understanding of individual responses and the planning of personalized clinical and nutritional interventions. The objective of this study is to evaluate clinical, nutritional, and metabolomic aspects of individuals with HFrEF and HFpEF treated in an outpatient settings. This is a descriptive cross sectional study conducted with adult and elderly individuals of both sexes diagnosed with heart failure. The sample consisted of 68 participants, who were divided into two groups: HFrEF (n = 44) and HFpEF (n = 24). For the metabolomic profile analyses, a subsample of individuals matched by sex and age was considered, with 44 participants having plasma samples: HFrEF (n = 22) and HFpEF (n = 22), and 28 participants having urine samples: HFrEF (n = 14) and HFpEF (n = 14). Sociodemographic, clinical, anthropometric, and biochemical data were collected. Food and dietary intake were assessed using 24-hour dietary recalls (24hR). The metabolomic profile was analyzed in plasma and urine samples using 1H nuclear magnetic resonance imaging. In the total sample, a predominance of males (63.2%) was observed, with a mean age of 55 years, former alcoholics (66.2%), with a mean body mass index (BMI) classified as overweight (26.5 kg/m2), systemic arterial hypertension (SAH) (66.2%), and absence of a diabetes diagnosis (66.2%). Individuals with HFrEF presented lower mean systolic blood pressure (SBP) values (p = 0.035), a higher frequency of diuretic use (70.2% vs. 29.8% p = 0.043), and higher serum transferrin values (p = 0.009) compared to the HFpEF group. Regarding food consumption, the HFrEF group showed a higher mean intake of legumes (p = 0.031), oils and fats (p = 0.019), and a tendency towards higher fish consumption (p = 0.067). Plasma metabolomic analysis identified creatine/phosphocreatine, glucose, choline/phosphocholine, and glycerol as possible differential metabolites associated with the HFrEF group, although no statistical significance between the groups was achieved. In turn, urine metabolomic analysis revealed 15 possible differential metabolites. Threonine, formate, 2-furoylglycine, and cis-aconitic acid were the main metabolites associated with the HFpEF group, while formate was more abundant in the HFrEF group, but without statistical significance. Despite the homogeneity of the groups, the findings indicate relevant differences between the HF phenotypes in clinical and dietary aspects. The results of the metabolomic analysis suggest urine as a more sensitive matrix for identifying distinct metabolic signatures between the groups, presenting potential differential biomarkers, which can assist in the personalization of clinical and nutritional treatment.

COMMITTEE MEMBERS:
Externo à Instituição - BANNY SILVA BARBOSA CORREIA - USP
Presidente - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA
Externa ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES - null