Banca de DEFESA: DÁLETE ASSÍRIA DE SOUZA RIBEIRO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : DÁLETE ASSÍRIA DE SOUZA RIBEIRO
DATE: 28/03/2025
TIME: 09:00
LOCAL: Sessão pública realizada por videoconferência
TITLE:

EFFECTS OF PROBIOTICS SUPPLEMENTATION ON THE ANTHROPOMETRY OF PATIENTS WITH TYPE 2 DIABETES MELLITUS: A SYSTEMATIC REVIEW AND META-ANALYSIS

KEY WORDS:

Intestinal microbiota 1. Body weight 2. Metabolic diseases 3.

PAGES: 108
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Diabetes Mellitus (DM) is characterized by hyperglycemia due to partial or severe deficiency of insulin secretion by pancreatic β cells. Previous studies have shown a relationship between the intestinal microbiota (IM) and type 2 Diabetes Mellitus (T2DM), sparking interest in probiotic supplementation to modulate IM and glucose metabolism in these patients, although the exact mechanisms remain unclear. Probiotics can influence metabolic factors and improve IM composition, possibly helping to reduce weight in patients with DM2. The objective of this review is to compile and analyze scientific evidence on the effects of probiotic supplementation on the anthropometry of patients with DM2. Methodological guidelines were followed in accordance with the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) statement, and the study was registered in the International Prospective Register of Systematic Reviews (PROSPERO) with reference number CRD42023480243. Randomized clinical trials were included, selected through an active search carried out in the PubMed, ScienceDirect, SCOPUS and Google Scholar databases using the search descriptors "intestinal microbiota", "body weight" and "metabolic diseases”. The assessment of the methodological quality of the studies was carried out using the Cochrane Collaboration instrument. The risk of bias analysis was carried out using the Revised Cochrane tool for risk of bias in randomized clinical trials (RoB 2). Probiotic supplementation resulted in a significant mean reduction of 1.95 cm in BW and 0.64 percentage points in HbA1c compared to placebo. Furthermore, there was a significant reduction in fasting blood glucose in studies that showed an impact on BMI. However, no significant changes were observed in the lipid and inflammatory profile. The meta-analysis evaluated the impact of probiotic supplementation on anthropometric and glycemic variables, with no significant effect on weight and BMI. However, a reduction in PC was observed in interventions longer than 8 weeks, with differences depending on the route of administration. Supplementation did not significantly improve fasting blood glucose or HbA1c, highlighting the need for more standardized studies to better understand its effects on body composition and metabolic health.

COMMITTEE MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa ao Programa - 2495705 - GRASIELA PIUVEZAM - nullExterna à Instituição - SIMONE DE VASCONCELOS GENEROSO - UFMG