Banca de DEFESA: RAYANE FELIPE DE FRANCA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RAYANE FELIPE DE FRANCA
DATE: 24/03/2025
TIME: 10:00
LOCAL: Departamento de Nutrição da UFRN e Via Google Meet
TITLE:

Association of ultra-processed food consumption with the antioxidant profile of breast milk and diet: a cross-sectional study

KEY WORDS:

Food consumption. Nova Classification. Antioxidant enzymes. Antioxidant activity. Lactation. Breastfeeding.

PAGES: 80
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Ultra-processed foods (UPF) tend to have a high oxidative capacity, contributing to the triggering of inflammatory processes and the emergence of related diseases. However, the impact of UPF consumption on the antioxidant profile of women during lactation is still unknown. Knowing that breastfeeding is essential for the healthy development of the child, providing growth factors, nutrients and a powerful antioxidant capacity via breast milk, the present study aimed to investigate the relationship between UPF consumption and the antioxidant profile of breast milk and the diet of 136 lactating women treated in primary health care in the city of Natal-RN, with a median of 66 days postpartum. The study was approved by the Research Ethics Committee of UFRN (CAAE 29928420.7.0000.5292). Socioeconomic and health identification information, anthropometric measurements, 24-hour recalls (R24h) adapted to the New Classification and aliquots of breast milk from a single breast were collected. To determine the antioxidant markers of breast milk, the antioxidant enzymes superoxide dismutase (SOD) and catalase were analyzed using commercial kits by plate reading, as well as the quantification of alpha-tocopherol by Ultra Performance Liquid Chromatography. The theoretical estimate of vitamin E supply via analyzed milk (4 mg of vitamin E in 780 mL per day) was also evaluated. Food consumption was evaluated according to the caloric participation of UPF in the diet (% EAUP) and the antioxidant profile of the diet according to the dietary intake of vitamin E (mg/day and mg/1000 kcal) and total antioxidant capacity of the diet (CATd mmol/day). Lactating women were grouped into tertiles of %EAUP. The association between UPF consumption (kcal) and markers of antioxidant profile in milk and diet were confirmed by adjusted multiple linear regression models. UPF accounted for almost 1/4 (24.3%) of dietary calories and it was observed that women in the highest tertile of %EAUP had higher intake of proteins, carbohydrates, lipids and fibers with significant difference and total antioxidant capacity of the diet (p<0.05). In breast milk, the alpha-tocopherol concentration had a median of 151.4 (Q1-Q3 101.0-258.0) μg/dL and 77.8% of the milks studied did not theoretically reach 4 mg/day of vitamin E. The SOD enzyme obtained a mean of 0.2 (0.1) U mg-1 and Catalase a median of 60.1 (Q1-Q3 10.6-60.1) U mg-1. With the adjusted linear regression analysis, a positive relationship was identified between UPF consumption (kcal) and SOD concentration (β = 0.00 95% CI -0.00-0.00 p<0.007), as well as with CATd (β = 0.01 95% CI 0.00-0.02 p<0.001). In the study population, higher UPF consumption affected an antioxidant marker in breast milk, and it is important to avoid its consumption during lactation to avoid inducing a pro-oxidant status of human milk. The relationship between UPF and dietary antioxidant capacity suggests that the CATd instrument needs to consider food processing for this purpose.

COMMITTEE MEMBERS:
Externa à Instituição - ANA MARA DE OLIVEIRA SILVA - UFS
Externa ao Programa - 1384055 - ILLANA LOUISE PEREIRA DE MELO - nullPresidente - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES
Externa ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES - null