Banca de DEFESA: LAISE MAYARA BARROS DE OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : LAISE MAYARA BARROS DE OLIVEIRA
DATE: 21/03/2025
TIME: 14:00
LOCAL: Departamento de Nutrição da UFRN e Via Google Meet
TITLE:

Evaluation of nutritional intervention in patients with cancer in the gastrointestinal tract

 

KEY WORDS:

Gastrointestinal Neoplasms. Nutritional Status. Nutritional Supplements. Perioperative Period.

PAGES: 54
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Cancer is a chronic disease characterized by abnormal and disordered cell growth that tends to invade neighboring tissues and organs. Patients undergoing surgical resection have malnutrition as a risk factor for postoperative complications. When dietary advice is ineffective, supplements help meet the patient's nutritional needs. The use of supplements with immunomodulatory nutrients such as arginine, glutamine, omega-3 fatty acids, and nucleotides helps modulate inflammation and increases protein synthesis after surgery. The objective of the present study was to evaluate the effect of nutritional intervention using immunomodulatory supplements in the postoperative period in malnourished patients with cancer of the gastrointestinal tract undergoing surgical treatment. This is a pragmatic clinical trial, which included 56 participants selected in an oncology unit, from June 2023 to October 2024. Data collection took place in the pre-surgical and post-surgical periods. Biochemical information was collected at the first moment and anthropometric data at both moments of the research. Participants were classified according to the Patient-Generated Subjective Global Assessment (PGSA) classification; those who were classified as well-nourished (group A) were guided on nutritional care in the postoperative period, according to the institutional protocol; and participants classified as having suspected, moderate or severe malnutrition (group BC) received the same guidance plus supplementation with an immunomodulatory formula for 10 days after surgery. The collected data were recorded in a pre-designed instrument containing fields for information on nutritional status, muscle reserve and function, and clinical outcomes. Regarding biochemical data, hemoglobin and hematocrit were below the reference value for both groups. Group A showed negative mean variations and significant differences between preand post-surgery regarding weight (mean variation = -5.0; p = 0.000), BMI (mean variation = -1.7; p = 0.000) and calf circumference (mean variation = -1.8; p = 0.007). Group BC also showed negative mean variation and significant differences for the variables weight (mean variation = -2.6; p = 0.000) and BMI (mean variation = -1.4; p = 0.000); however, it was noted that group BC showed less loss when compared to group A, in an average period of 22 days. Adherence to the supplement in malnourished patients promoted less weight loss, less variation in BMI, arm circumference, calf circumference and handgrip strength when compared to the group classified as well-nourished evaluated pre- and post-surgery. These findings highlight the importance of nutritional intervention in the treatment and nutritional status of patients with cancer in the gastrointestinal tract

COMMITTEE MEMBERS:
Externa à Instituição - AYANE CRISTINE ALVES SARMENTO - LNRCC
Externa à Instituição - CAMILA XAVIER ALVES
Presidente - 4659679 - SANCHA HELENA DE LIMA VALE
Interna - 1452705 - SEVERINA CARLA VIEIRA CUNHA LIMA