Banca de QUALIFICAÇÃO: EDUARDO RODRIGUES DE SENA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : EDUARDO RODRIGUES DE SENA
DATE: 22/01/2024
TIME: 14:00
LOCAL: Centro de Biociências
TITLE:

HEMATOLOGICAL EVALUATION AND INFECTIOUS DISEASES ASSOCIATED WITH
MANIFESTATION OF GENERALIZED CANINE DEMODICOSIS IN ADULTS

KEY WORDS:

Canine demodicosis; Generalized demodectic mange; Demodex spp.

PAGES: 41
BIG AREA: Ciências Biológicas
AREA: Parasitologia
SUMMARY:

Canine demodicosis is an inflammatory disease of the skin of dogs caused by the proliferation
excessive growth of the mite Demodex spp., normally a commensal of the skin. The clinical manifestation
is related to host genetic factors, use of immunosuppressive drugs,
neoplasms and decreased or failed immune response due to infectious diseases
concomitants. The objective of the project was to carry out hematological, biochemical and
infectious diseases associated with the manifestation of generalized canine mange caused
by Demodex spp. in adult dogs. For this, 16 dogs with symptoms were recruited
demodectic mange clinic, among which 7 affected the generalized form of the disease.
The most prevalent skin lesion was alopecia (100% of dogs), followed by
desquamation in 75% of the dogs evaluated. Pododemodicosis and erythema were present
only in the 7 dogs diagnosed with generalized demodicosis. Serological tests
revealed the presence of antibodies against Ehrlichia canis/ewingii in 100% of dogs
evaluated. Furthermore, the presence of antibodies against Leishmania was detected
infantum and Anaplasma platys/phagocytophilum in dogs carrying generalization of
demodectic mange (28.6%), as well as Dirofilaria immitis (14.3%) antigens. All 7
dogs with generalized demodectic mange showed monocytosis and MCHC values
below the reference, among which 6 also had leukocytosis and/or
thrombocytopenia. Furthermore, neutrophilia and eosinophilia were present in 4 dogs with the form
generalized demodicosis, and lymphocytosis in only 1 of them. Biochemical assessment
revealed elevated AST values in 3 dogs with generalized demodicosis and increased AST
in just one of them. The urea and creatinine values were within the
reference in all dogs with generalized demodectic mange. Taken together, the data
demonstrate hematological and biochemical changes in dogs with demodicosis
widespread. A better understanding of the factors that lead to development
of generalized demodicosis in adult dogs may serve as a basis for the development
of combined therapeutic strategies that optimize the resolution of the clinical condition, as well as
how to impede its development.

COMMITTEE MEMBERS:
Externa à Instituição - ALESSANDRA FERREIRA DA SILVA
Interno - 2611909 - CARLOS RAMON DO NASCIMENTO BRITO
Presidente - 3146620 - MANUELA SALES LIMA NASCIMENTO