Banca de QUALIFICAÇÃO: RAYANE FRANÇA DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RAYANE FRANÇA DA SILVA
DATE: 08/08/2022
TIME: 08:30
LOCAL: Sala da Pós-graduação
TITLE:

IMPACT OF THE COVID-19 PANDEMIC ON THE PROFILE OF BACTERIAL RESISTANCE IN A HOSPITAL IN THE CITY OF NATAL-RN

KEY WORDS:

Antibiotics; Covid-19; Health-related infection; Bacterial resistance; Coinfection; Multi-resistance.

PAGES: 85
BIG AREA: Ciências Biológicas
AREA: Microbiologia
SUMMARY:

Antimicrobial resistance is a public health problem of global importance, which occurs naturally due to the ability of bacteria to adapt to changes in the external environment. The exacerbated use of antimicrobials, particularly in intensive care units (ICU), has contributed considerably to the development and selection of new mechanisms of bacterial resistance. The emergency of Covid-19 brought an uncertain epidemiological and sanitary scenario, resulting in an increase in the empirical use of antimicrobials for the treatment of bacterial infections acquired secondary to viral infection in patients hospitalized in ICUs. Therefore, this study aims to evaluate the impact of the Covid-19 pandemic on the bacterial resistance profile in a private hospital located in the city of Natal-RN. This is a cross-sectional descriptive study of a retrospective nature, in which the resistance profile of bacterial isolates from adult patients hospitalized over a period of three years, covering before and during the Covid-19 pandemic, was evaluated. Through the notification sheets of the Hospital Infection Control Service (SCIH) of the Hospital studied, there were about 4,361 positive cultures in the period of 3 years, being 22% in 2019, 37% in 2020 and 41% in 2021. Patients males and females were equally affected and the mean age found was equal to 63 years. An increase in the occurrence of infections in older age groups was observed in cases involving patients with a mean age of ≥64 years. Patients with Covid-19 accounted for 14% of the total positive cultures. The microorganisms isolated belong, for the most part, to the group of Gram-negative bacteria, with the following species being more prevalent: Klebsiella pneumoniae (24.2%), Pseudomonas aeruginosa (20.1%), Escherichia coli (10.2%), Acinetobacter baumannii (2.5%) and Enterobacter spp. (2.1%). The most observed resistance mechanism was ESBL (6.5%), KPC (5.4%) and Metallo-β-lactamase (1.7%). It was observed that the public most affected by resistant bacteria were adult and elderly patients associated with Covid-19. Data reported for antimicrobial classes were significant for the increase in resistance to 4th Generation cephalosporins (p=0.001); Carbapenems (p=0.005); Aminoglycosides (p<0.001) and Fluoquinolones (p<0.001), when compared to the normal perspective of evolution of infections in patients negative for Covid-19. This emphasizes the importance of retrospective studies on bacterial resistance after Covid-19, for taking preventive measures and socio-normative behaviors correlated with the health and well-being of the population.

COMMITTEE MEMBERS:
Presidente - 1452833 - MARIA CELESTE NUNES DE MELO
Interno - 348473 - JOSE VERISSIMO FERNANDES
Externo ao Programa - 3527859 - ERMETON DUARTE DO NASCIMENTO - UFRN