Banca de QUALIFICAÇÃO: RAMAYANA MORAIS DE MEDEIROS BRITO

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : RAMAYANA MORAIS DE MEDEIROS BRITO
DATA : 01/03/2019
HORA: 09:30
LOCAL: Sala de reuniões do Centro de Biociências.
TÍTULO:

INFLAMMATORY ASPECTS OF CYSTOGENIC CEPA INFECTION BY TOXYPLASMA GONDII IN ISOGENIC MURINE MODEL AND OUTBRED.

PALAVRAS-CHAVES:

Toxoplasma gondii; inflammation; Toxoplasmosis

PÁGINAS: 80
GRANDE ÁREA: Ciências Biológicas
ÁREA: Parasitologia
RESUMO:

Toxoplasmosis is a zoonosis widely distributed throughout the world, caused by Toxoplasma gondii, an obligate intracellular protozoan capable of invading and multiplying in any nucleated cell. After invasion, the parasite triggers the activation of a pro-inflammatory response, capable of stimulating its encistamento and maintenance of the chronic infection. This antiparasitic response, when exacerbated, can generate immunopathological changes in the host organism. However, in order to avoid tissue compromise, the immune system establishes a balance through the anti-inflammatory response. However, the parasite has mechanisms to manipulate the immune system in order to establish a persistent and efficient infection, contributing to the development of brain changes as a consequence of chronic neuroinflammation. In this context, the objective of this work was to evaluate the effects of T. gondii cystogenic strain on the inflammatory response in isogenic mice (Balb / ce C57BL / 6) and outbred (Swiss), related to neuropathological features characteristic of the infection cerebral. Among the infected groups, all lineages presented body weight loss and evident signs of acute infection, with reactivity index (IR) for anti-T IgG. gondii, characterizing the positivity of the infection. The quantification of proinflammatory cytokines showed that the production of IFN-γ, IL-12 and TNF-α by the infected groups of the three strains was higher than those presented by the control groups, reinforcing the importance of a pro- effective in the process of chronic infection. In contrast, for anti-inflammatory cytokines, TGF-β production was more pronounced only by the Balb / ce infected group, for IL-10, the three lines showed similar and high values, indicating the immunoregulation involvement in the balance of developed pathogenesis. These data reinforce the importance of the development of an efficient immune response in the maintenance of the cysts found in the brain, characteristic of the chronic infection, varying according to the profile presented by the different strains of mice.

MEMBROS DA BANCA:
Presidente - 2213126 - VALTER FERREIRA DE ANDRADE NETO
Interno - 1752367 - PAULO MARCOS DA MATTA GUEDES
Externa ao Programa - 1996107 - LIA REJANE MULLER BEVILAQUA