Banca de QUALIFICAÇÃO: THIALA SOARES JOSINO DA SILVA PARENTE

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : THIALA SOARES JOSINO DA SILVA PARENTE
DATE: 15/08/2025
TIME: 09:00
LOCAL: VIDEOCONFERÊNCIA
TITLE:

Effect of Moringa oleifera on inflammatory diseases: an umbrella review of 26 systematic reviews

KEY WORDS:

moringa, inflammation, phytotherapy, systematic review, overview.

PAGES: 94
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Moringa oleifera Lam (Moringaceae), popularly known as the “tree of life”, “thigh tree”,

“horseradish tree” or “miracle tree”, is native to India and Africa and cultivated in many

tropical and subtropical regions of the world. Several pharmacological activities have been

associated with the species, including neuroprotective, antimicrobial, antiasthmatic,

antimalarial, cardioprotective, antidiabetic, antiobesity, hepatoprotective and anticancer.

Among these activities, the effect of attenuating the negative impact of chronic inflammation

and its action against associated disorders have been highly evidenced. This anti-inflammatory

capacity has been attributed to the content of glucosinolates, flavonoids and phenolic acids

present in the plant. Although there is much evidence in the literature about its benefits, there

is a lack of standardization of products derived from M. oleifera (MO) that have anti

inflammatory action. Objectives: To summarize and critically analyze the quality of evidence

from systematic reviews (SRs) and meta-analyses (MAs) that evaluated the efficacy of OM in

the treatment of inflammatory diseases, understand the main pathways activated during this

exposure, and correlate the type of product obtained with the species that was evaluated.

Methodology: A systematic literature search was conducted from inception to November 4,

2024, using the Embase, Scopus, Web of Science, PubMed/Medline, and Cochrane Library

databases. Eligibility criteria were (i) SRs on OM; (ii) SRs on OM related to inflammatory

diseases; (iii) No limitations on language, year, and model. Literature selection and data

extraction were conducted by two independent reviewers. The quality of SRs was assessed using

the PRISMA checklist and the adapted AMSTAR-2 tool. Results and discussion: Twenty-six SRs

were included, covering a total of 573 primary articles. MO leaves were the most commonly

used parts of the plant; decoction was the main extraction method; ingestion of encapsulated

powder, in tablets or added to a meal, was the main preparation method; water and ethanol

were the most commonly used solvents; and flavonoids, phenolic acids, and isothiocyanates

were the main constituents involved in MO activities. Many SRs showed promising efficacy of

MO for diabetes mellitus, obesity, cancer, hypertension, dyslipidemia, among other conditions,

but the quality of these SRs was questionable. Only 6 SRs indicated that they followed PRISMA

(2020), and yet they did not reach even 80% compliance with the checklist in our evaluation.

The SRs were predominantly classified as of low methodological quality (≤ 7/16) after the

application of AMSTAR-2. NF-kB and Nrf2 appear to be the pathways involved in the anti

inflammatory and antioxidant mechanisms of MO, respectively. Conclusions: MO is a

promising plant for health care and beneficial in the treatment of inflammatory diseases.

However, considering the low quality level of different studies, in which most presented a lack

of standardization in their protocol (dose and pharmaceutical form used, use of plant powder

instead of extract, type of extraction, identification and quantification of the chromatographic

profile and marker for quality control), studies with better planning are necessary to confirm

that the use of this plant is safe and effective.

COMMITTEE MEMBERS:
Presidente - 1639820 - ARNOBIO ANTONIO DA SILVA JUNIOR
Externo à Instituição - KLEYTON SANTOS DE MEDEIROS - LNRCC
Interno - 2432313 - RAND RANDALL MARTINS