A scaled up microemulsion formulation for insoluble compounds
Microemulsion, amphotericin B, scale up.
ABSTRACT: The microemulsions are reported to be an important alternative to improve drug solubility, enhance bioavailability, protect it against environmental conditions, extending thereby, the shelf life. However, during the development of this system, the possible combinations of its constituents can reach an endless number. Thus, the aim of this study was to use design of experiment approach and pseudoternary phase diagram to develop a microemulsion formulation easy to prepare and to scale up to pharmaceutical purposes, using amphotericin B as drug model. The selected system presented an isotropic behavior, stable granulometry (11,6 ± 0,023 nm) during the study (180 days), and high amphotericin B content (185 μg/mL). These results indicate that ME could be considered as an efficient and highly stable drug delivery system by providing an increase the poor bioavailability of AmB.