Identification of chromosomal changes representative of a molecular diagnosis of cleft lip and palate, using microarray genomic hybridization
Child; Comparative Genomic Hybridization; DNA Copy Number Variations; Cleft lip and palate.
Considering that the etiology of cleft palate (FLP) is not yet fully elucidated and that the identification of candidate genes is complicated by the heterogeneity in the involvement of major and minor genes, non-Mendelian inheritance patterns, as well as the involvement of submicroscopic genomic alterations not detectable in conventional methodologies, the present work aims to identify possible submicroscopic genomic alterations, representative of a molecular diagnosis of FLP, using the microarray genomic hybridization technique.