Banca de DEFESA: EMANUELL DOS SANTOS SILVA

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : EMANUELL DOS SANTOS SILVA
DATE: 24/08/2023
TIME: 14:00
LOCAL: Videoconferência
TITLE:

NANOPARTÍCULAS POLIMÉRICAS CATIÔNICAS COMO POTENCIAL IMUNOADJUVANTE CONTRA Trypanosoma cruzi

KEY WORDS:

Cationic nanoparticles; immunoadjuvants; T. cruzi extract; immune response modulation;

PAGES: 111
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Chagas disease is caused by the parasite Trypanosoma cruzi and is considered

 

a neglected tropical disease. Novel immunoadjuvants have been studied to

 

improve the immune response and treatment efficacy. Nanoparticles are drug

 

delivery devices that target specific cells, enhancing therapeutic action and may

 

possess immunomodulatory characteristics. This study explored the use of

 

cationic PLGA-PEI nanoparticles as potential immunoadjuvants in response to

 

T. cruzi infection. The results obtained were satisfactory and promising. During

 

the research, it was demonstrated that cationic nanoparticles interacted with

 

proteins and exhibited favorable properties, such as appropriate size and

 

cellular viability. When tested as immunoadjuvants in animal models, the

 

nanoparticles stimulated an immune response similar to aluminum hydroxide, a

 

commonly used human immunoadjuvant. Furthermore, the nanoparticles were

 

observed to stimulate the production of high avidity and specific antibodies of

 

subclasses IgG2b and IgG3, which play important roles in the inflammatory

 

process and effector cell activity. These findings are relevant as the formulated

 

nanoparticles are unprecedented in the literature and demonstrate significant

 

potential for the development of immunomodulatory strategies in the context of

 

T. cruzi infection.

 

COMMITTEE MEMBERS:
Presidente - 1639820 - ARNOBIO ANTONIO DA SILVA JUNIOR
Externa ao Programa - ***.000.000-** - CLÁUDIA JASSICA GONÇALVES MORENO - UFRN
Externo à Instituição - JOSÉ LAMARTINE SOARES SOBRINHO - UFPE
Externo à Instituição - MARCELA RAQUEL LONGHI - UNC/AR
Interno - 1544647 - MATHEUS DE FREITAS FERNANDES PEDROSA