Banca de QUALIFICAÇÃO: GEORGE ALEXANDRE LIRA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : GEORGE ALEXANDRE LIRA
DATE: 12/09/2024
TIME: 08:00
LOCAL: REMOTA - https://meet.google.com/nsm-irdo-hjx
TITLE:

High M2-TAM infiltration and STAT3/ NF-κB signaling pathway as predictive factors for tumor progression and death in cervical cancer.

KEY WORDS:

M2-TAM; STAT3; Cervical Cancer; recurrence; Overall survival; Tumor progression

PAGES: 32
BIG AREA: Ciências da Saúde
AREA: Enfermagem
SUMMARY:

Introduction: The tumor microenvironment (TME) plays a crucial role in the progression, invasion, and metastasis of cervical carcinoma (CC). Tumor-associated macrophages (TAMs) are significant components of the CC TME, but studies on their correlation with CC progression are still controversial. This study aimed to investigate the relationship between TAM infiltration, the STAT3/NF-κB signaling pathway and Overall Survival (OS) in CC patients. Methods: In a retrospective study, 691 CC patients who had received a definitive histopathologic diagnosis of CC scored by the FIGO staging system and not undergone preoperative treatment were selected from a database. The effect of TAM infiltration on tumor progression biomarkers using Tissue Microarray (TMA) and immunohistochemistry was evaluated. Furthermore, the impact of the expression of these biomarkers and clinical-pathological parameters on Recurrence-free (RF) and OS using Kaplan-Meier and multivariable Cox regression methods was also analyzed. Results: High stromal CD163+204+TAMs density and via STAT3 and NF-κB pathways was relevant to the expression of E-cadherin, Vimentin, MMP9, VEGFa, Bcl-2, Ki-67, CD25, MIF, FOXP3 and IL-17, (all, p<0.0001). In addition, elevated TNM staging IV had a strong association correlation with STAT3 and NF-κB pathways (p<0.0001), CD25 (p<0.001), VEGFa (p<0.001), MIF (p<0.0001) and Ki-67 (p<0.0001). On the other hand, overall and recurrence survival was shown to be strongly influenced by the expression of SNAIL (HR= 1.52), E-cadherin (HR= 1.78), Ki-67 (HR= 1.44). Conclusion: M2-TAM and via STAT3/NF-κB pathways had a strong effect on CC tumor progression which reverberated in the severity of clinicopathological findings, becoming an important factor of poor prognosis.

COMMITTEE MEMBERS:
Externo ao Programa - 1161638 - FRANCISCO EDILSON LEITE PINTO JUNIOR - nullExterna à Instituição - KARUZA MARIA ALVES PEREIRA - UFC
Presidente - 2329140 - RAIMUNDO FERNANDES DE ARAUJO JUNIOR