Banca de DEFESA: GEOVANNA BEATRIZ OLIVEIRA ROSENDO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : GEOVANNA BEATRIZ OLIVEIRA ROSENDO
DATE: 28/05/2024
TIME: 14:30
LOCAL: REMOTO: https://meet.google.com/vsz-uhxn-kpj
TITLE:

EFFECT OF EXPOSURE TO ARSÊNIO, CHUMBO, MERCURIUM AND CADMIUM ON LIPID AND GLYCEMIC PROFILE

KEY WORDS:

Glycemic control, disorders of lipid metabolism, cadmium, mercury, arsenic, lead

PAGES: 15
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Contamination by toxic elements, including arsenic (As), lead (Pb), mercury (Hg) and cadmium (Cd), represents a global problem associated with harmful effects on human health, which can cause metabolic changes. However, understanding the impact of exposure to toxic elements on glycemic and lipid profiles remains incomplete. This dissertation consists of two studies: the first is a systematic review and meta-analysis of observational studies (Study 1), and the second, a narrative review (Study 2). Study 1 aimed to answer the following question: “Is exposure to As, Pb, Hg and Cd associated with changes in lipid and glycemic profiles in humans?” The review is registered with PROSPERO (CRD42023393681) and was developed based on the Preferred Reporting Items for Systematic Review and Metaanalysis (PRISMA). Studies involving individuals over 10 years of age were included, containing an exposed group and a group not exposed (or with low exposure) to As, Pb, Hg and Cd, published until March 2024. Fasting blood glucose and lipoprotein low density (LDL-C) were defined as the primary outcomes. Secondary outcomes include glycated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG). The search, selection, extraction and quality analysis process were carried out independently, by two reviewers. The searches were conducted in the MEDLINE (PubMed), EMBASE, Web of Science, LILACS and Google Scholar databases and analyzes of risk of bias and methodological quality of the included studies were carried out using the modified Newcastle–Ottawa (NOS) and JBI tools. Critical Appraisal Tool. Stata statistical software (Stata Corp., College Station, TX, USA) was used to conduct the meta-analysis. Continuous variables were represented as standardized mean difference (SMD) with 95% confidence intervals (CIs). Heterogeneity between studies was verified by the I² test. The search strategy resulted in 6,020 reported articles, remaining at the end of the selection, 17 studies for narrative synthesis (systematic review). Among the selected articles, adverse effects on the concentration of fasting blood glucose, HbA1c, HDL-C and LDL-C were identified in individuals exposed to As. Individuals exposed to Hg showed an increase in TC and TC concentrations. Exposure to Pb was associated with changes in glycemic metabolism and increased concentrations of LDL-C, TC and TG. Finally, exposure to Cd was related to an increase in HbA1c, TC, LDL-C and TG concentrations, in addition to a reduction in HDL-C concentration. Two other studies did not report changes in the components of the glycemic profile in relation to exposure to Cd and Pb. In Study 2, the narrative review aimed to investigate the metabolic aspects of As and its mechanism of action associated with glycemic changes. A keyword combination of meSH terms was used to construct search equations Studies published in English in the PubMed (MEDLINE) and Google Scholar databases were screened, resulting in 466 articles identified, of which only 50 were included in the review. It was observed that the relationship between exposure to As and glycemic changes in humans may be associated with factors such as sex, smoking, body mass index, age, occupation and genetic factors. It is suggested that the findings of the two studies may emphasize the importance of identifying environmental exposure to As, Pb, Hg and Cd and their associations with changes in lipid and glycemic profiles.

COMMITTEE MEMBERS:
Externo à Instituição - ANDERSON MARLIERE NAVARRO - USP
Presidente - 6349432 - LUCIA DE FATIMA CAMPOS PEDROSA
Externa ao Programa - 1055045 - MARCELA ABBOTT GALVAO URURAHY - null