Banca de DEFESA: JOANNA DE ANGELIS DA COSTA BARROS

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE: JOANNA DE ANGELIS DA COSTA BARROS
DATA: 28/03/2012
HORA: 14:00
LOCAL: Sala Karl Peter von Dietrich - CB
TÍTULO:

AVALIAÇÃO DA ATIVIDADE ANTIOXIDANTE E ANTIPROLIFERATIVA DO EXTRATO AQUOSO DE FRUTAS TROPICAIS

PALAVRAS-CHAVES:

antioxidante; atividade abtiproliferativa; frutas tropicais; alimentos funcionais

PÁGINAS: 80
GRANDE ÁREA: Ciências Biológicas
ÁREA: Bioquímica
RESUMO:

The antioxidant activity of aqueous extracts of five edible tropical fruits (Spondias lutea, Hancornia speciosa, Spondias purpurea, Manilkara zapota and Averrhoa carambola) was investigated using different methods. The amount of phenolic compounds was determined by the Folin-Ciocalteu reagent. Extracts showed neither reducing power nor iron chelation (between 0.01 and 2.0 mg/mL). H. speciosa exhibited the highest superoxide scavenging activity (80%, 0.5 mg/mL). However, at high concentrations (8.0 mg/mL) only A. carambola, S. purpurea and S. lutea scavenging 100% of radicals formed. M. zapota and S. purpurea had higher phenolic compound levels and greater OH radical scavenging activity (92 %, 2 mg/mL). Antiproliferative activity was assessed with 3T3 fibroblasts and cervical tumor cells (HeLa). The most potent extract was S. purpurea (0.5 mg/mL), which inhibited Hela cell proliferation by 52%. All fruits showed antioxidant and antiproliferative properties, characterizing them as functional foods.

MEMBROS DA BANCA:
Presidente - 2195251 - HUGO ALEXANDRE DE OLIVEIRA ROCHA
Externo ao Programa - 1149646 - LUIZ ROBERTO DIZ DE ABREU
Externo à Instituição - VALQUIRIA PEREIRA DE MEDEIROS - UNIFESP