Banca de DEFESA: FRANCISCO HUMBERTO XAVIER JUNIOR

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.

DISCENTE: FRANCISCO HUMBERTO XAVIER JUNIOR

DATA: 30/06/2011

HORA: 08:30

LOCAL: Sala do Departamento de Farmácia

TÍTULO:

PROSPECTIVE STUDY FOR DEVELOPMENT OF EMULSION SYSTEMS CONTAINING NATURAL OIL PRODUCTS

PALAVRAS-CHAVES:

Emulsion, Copaiba oil, Hydrophilic-Lipophilic Balance, pseudo-ternary phase diagram, rheological analysis

PÁGINAS: 67

GRANDE ÁREA: Ciências da Saúde

ÁREA: Farmácia

RESUMO:

Background: Copaiba oil (Copaifera langsdorffii Desf.), a natural product widely used “in natura” as an anti-inflammatory and anti-infective agent, presents two major problems: (i) low absorption and bioavailability and (ii) an unpleasant taste. The aim of this study was to develop copaiba oil emulsion systems. The critical hydrophilic-lipophilic balance (HLBc) of copaiba oil was determined for oil-in-water emulsion. The system was characterized in a pseudo-ternary phase diagram (PTPD). A study about the physicochemical stability and the preparation methods was carried out. Methods: Once an appropriate emulsion was achieved, the samples were prepared employing the phase inversion temperature method using different surfactant binary mixtures to obtain a range of HLB values between 4.5 and 16.5. Therefore, the HLBc of copaiba oil for O/W emulsion was calculated. The PTPDs were produced by the titration method. The stability study was conducted up to one year, to evaluate the efficiency of the preparation methods of the systems. Results: The HLB value of copaiba oil for O/W emulsion was 14.8. The PTPDs were useful to describe the component proportions to form several colloidal systems. The rheological studies revealed that the formulations presented a non-Newtonian flux with pseudoplastic and thixotropic characteristics. The proposed carrier emulsion system remained pharmaceutically stable for more than one year. The stability data revealed that no significant physicochemical instability occurred in the samples in the experimental conditions. In conclusion, these results indicate that copaiba oil emulsion might be a promising vehicle for topical delivery of drugs and active cosmetic ingredients.

MEMBROS DA BANCA:
Presidente - 1178187 - ERYVALDO SOCRATES TABOSA DO EGITO
Externo ao Programa - 1714294 - MARCIO FERRARI
Externo à Instituição - RUY CARLOS RUVER BECK - UFRGS