Banca de DEFESA: RAYNARA BOLCONT DE OLIVEIRA GOMES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : RAYNARA BOLCONT DE OLIVEIRA GOMES
DATE: 21/10/2026
TIME: 09:00
LOCAL: REMOTA
TITLE:

BEYOND SYMPTOM REDUCTION: N,N-DIMETHYLTRYPTAMINE IMPROVES ANXIETY, LIFE SATISFACTION, AND QUALITY OF LIFE IN HEALTHY VOLUNTEERS AND PATIENTS WITH DEPRESSION

KEY WORDS:

N,N-dimethyltryptamine, anxiety, life satisfaction, quality of life, depression, treatment-resistant depression.

PAGES: 56
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Given the current landscape of psychedelic research, there is a growing effort to move beyond the narrow focus on the remission of psychopathological symptoms, shifting attention toward multidimensional dimensions of subjective well-being. From this perspective, N,N-dimethyltryptamine (DMT) is being tested as a potential rapid-acting antidepressant, and studies have been exploring its impacts on anxiety, quality of life, and life satisfaction in both healthy volunteers and patients with Treatment-Resistant Depression (TRD). This longitudinal analysis study derives from two exploratory open-label clinical trials. To evaluate the variables of interest, validated psychometric instruments were administered across multiple time points, including the State-Trait Anxiety Inventory (STAI-S), the WHOQOL-BREF (general quality of life) and WHOQOL-SRPB (spirituality, religion, and personal beliefs) scales, and the Satisfaction with Life Scale (SWLS), alongside tools specifically measuring altered states of consciousness and the depth of the mystical experience (HRS, 5D-ASC, and MEQ-30), as well as psychiatric assessments (MADRS, PHQ-9, BSI). Exploratory findings revealed a reduction in state anxiety up to 1 day post-inhalation across all volunteers. Healthy volunteers reported increased life satisfaction up to 14 days post-administration following DMT exposure. Among patients, increased life satisfaction was reported at 12 months, along with sustained improvements in quality of life over this period, including Physical Health, Psychological Health, Social Relationships, and Environment (WHOQOL-BREF), as well as partial improvements in Inner Peace and Hope & Optimism (WHOQOL-SRPB). Therefore, this study suggests that DMT drives multidimensional improvements, fostering enhanced psychological functioning and recovery, including existential and functional domains. Given the scarcity of research in this area, these results contribute to advancing this emerging field and fostering a broader understanding of the potential mechanisms of DMT.

COMMITTEE MEMBERS:
Externo à Instituição - AURINO LIMA FERREIRA - UFPE
Presidente - 1243905 - DRAULIO BARROS DE ARAUJO
Externa ao Programa - 1718518 - NICOLE LEITE GALVAO COELHO - null