Banca de QUALIFICAÇÃO: ANNY CRISTINE DE ARAUJO

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ANNY CRISTINE DE ARAUJO
DATE: 27/02/2026
TIME: 14:00
LOCAL: REMOTA
TITLE:

GENOMIC INSTABILITY IN SEVERE PREECLAMPSIA: ASSOCIATIONS WITH GESTATIONAL RISK, CLINICAL SEVERITY, AND VITAMIN E DEFICIENCY

KEY WORDS:

Vitamin E; Antioxidants; Pregnant women; Micronuclei; Pre-Eclampsia

PAGES: 26
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:

Introduction:

Pregnancy involves physiological adaptations that may intensify oxidative stress and genomic instability, particularly in preeclampsia. Cytogenetic biomarkers assessed by the cytokinesis-block micronucleus (CBMN) assay allow the quantification of such damage; however, the integration of gestational risk, clinical severity, and nutritional factors remains insufficiently explored.

Objectives:

To evaluate the association between gestational risk estimated early in pregnancy, clinical severity of preeclampsia in the third trimester, and maternal genomic instability, considering clinical, anthropometric, and nutritional parameters, with emphasis on vitamin E.

Results:

A total of 62 pregnant women with severe preeclampsia were evaluated, with a median gestational age of 32.6 weeks (95% CI: 31.7–33.2) and elevated blood pressure levels [SBP: 162.0 mmHg; DBP: 101.0 mmHg]. Serum vitamin E concentration showed a median of 4.32 µmol/L (3.52–5.87), classifying 100% of participants as deficient, while dietary intake presented a median of 5.90 mg/day (5.48–6.88), with inadequacy observed in approximately 61%. Among cytogenetic biomarkers, nuclear buds were the most prevalent [16‰ (13.8–18.5)], followed by micronuclei [12‰ (12.7–16.8)] and nucleoplasmic bridges [10‰ (10.3–15.6)]. Diastolic blood pressure was positively correlated with the total frequency of nuclear abnormalities (r = 0.362; p = 0.007) and nucleoplasmic bridges (r = 0.325; p = 0.015), remaining independently associated in adjusted models (β = 0.343; p = 0.020). Nuclear bud frequency was significantly higher in more severe clinical presentations, regardless of the gestational risk previously assigned (p < 0.05).

Conclusion:

Maternal genomic instability in preeclampsia is mainly associated with elevated diastolic blood pressure, gestational weight gain, and vitamin E deficiency. Nuclear buds emerge as a sensitive biomarker of clinical disease severity, reinforcing the role of antioxidant nutritional status and hemodynamic control in modulating cellular damage in pregnant women with preeclampsia.

COMMITTEE MEMBERS:
Presidente - 2323511 - ADRIANA AUGUSTO DE REZENDE
Externa ao Programa - 1837366 - DANIELLE SOARES BEZERRA - nullExterna à Instituição - JULIANA DA SILVA