Banca de QUALIFICAÇÃO: FELIPE SANDERSON RIBEIRO DE SOUSA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : FELIPE SANDERSON RIBEIRO DE SOUSA
DATE: 30/06/2025
TIME: 09:00
LOCAL: REMOTA - https://meet.google.com/pdc-fkgd-jrj
TITLE:

SPATIOTEMPORAL DISTRIBUTION OF HUMAN AND CANINE VISCERAL LEISHMANIASIS IN RIO GRANDE DO NORTE, BRAZIL, 2019-2023

KEY WORDS:

Visceral Leishmaniasis; Spatial Analysis; Epidemiology aspects; Public health.

PAGES: 25
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

A retrospective study on the spatiotemporal distribution and clinical-epidemiological variables of autochthonous cases of Human Visceral Leishmaniasis (HVL) and Canine Visceral Leishmaniasis (CVL) was conducted in the state of Rio Grande do Norte (RN) and the municipality of Natal/RN, Brazil, from 2019 to 2023. HVL data were retrieved from the Notifiable Diseases Information System (NDIS), while CVL and phlebotomine data were obtained from the Zoonosis Surveillance Unit of Natal/RN (ZSU-Natal). The analyzed variables included the number of cases, Incidence Rate (IR), case Fatality Rate, and the epidemiological profile from 2019 to 2023. The spatial analyses performed included the incidence rates of HVL and CVL to assess spatial distribution. The Local Indicator for Spatial Association (LISA) was used to identify spatial autocorrelation, Kernel Density Estimation (KDE) was applied to detect spatial clusters of HVL and CVL incidence rates, and spatial scan statistics (Scan) were employed to identify spatiotemporal clusters. The distribution of HVL cases was observed in 18% (30/167) of the municipalities in the state of RN from 2019 to 2023. The municipalities with the highest number of cases were Natal, accounting for 46.9% (204/435), and Mossoró, with 6.4% (28/435). The HVL infection rate progressively declined from 2019 to 2021, while the CFR showed an inverse trend, with higher percentages during the same period. Regarding the epidemiological profile of HVL in the state, the majority of affected individuals were male (75.6%), with the infection being more frequent among those over 20 years of age, brown skin (68.5%), with elementary education (44.1%), and co-infected with HIV (34.9%). KDE analysis in the municipality of Natal/RN identified high-density hotspot clusters, and the high-high LISA pattern was concentrated in the North zone for both HVL and CVL. The spatiotemporal scan for CVL detected two clusters: one in the North zone and another in part of the East zone, while a significant cluster for HVL was identified in the North zone (Redinha neighborhood). The spatiotemporal analysis indicated a higher risk of human and canine infection in the North and East zones of the municipality. The study revealed that the spatial distribution patterns of VL remain a significant urban public health concern in the state of RN. The distribution of CVL and HVL was heterogeneous and widespread, with a marked concentration in the peripheral areas of Natal/RN.

COMMITTEE MEMBERS:
Externa ao Programa - 1714243 - DANIELLA REGINA ARANTES MARTINS SALHA - nullExterna à Instituição - JOANNA GARDEL VALVERDE GALVÃO - UFRN
Presidente - ***.985.294-** - LUCIA MARIA DA CUNHA GALVAO - UFRN