Influence of Dietary Patterns on the Risk of Thyroid Cancer
Thyroid neoplasms, dietary pattern, diet, risk factors, systematic review, meta-analysis.
The incidence of thyroid cancer has increased, and it is not entirely possible to attribute this continuous growth to more meticulous thyroid nodule selection and more accurate diagnostic techniques. Some research suggests a possible relationship between dietary patterns and the risk of thyroid cancer. Although there is currently no conclusive evidence linking dietary factors to thyroid cancer, certain dietary patterns seem to have an impact on the development of the disease. A deeper understanding of the underlying mechanisms should help identify modifiable risk factors for thyroid cancer. The present dissertation aimed to seek an association between dietary pattern and risk of thyroid cancer. The databases used for research for observational studies that investigated the association between dietary pattern and risk of thyroid cancer were PubMed/Medline, Embase, Scopus, Web of Science and LILACS. No language or year of publication has been imposed. Three impartial reviewers participated in the selection and extraction of data from original publications. Accomplished between September 2023 and January 2025. The Newcastle-Ottawa Quality Scale (NOS) assessed the risk of bias. Of the 45 studies were included (2 cross-sectional, 13 cohorts and 30 case-control), 40 showed association of consumption of the a posteriori pattern and 5 of a priori pattern. Significant results for food patterns a posteriori revealed that characterized food patterns rich in foods based on vegetables and fruits, as well as fish, low-fat meat, dairy, and unsaturated fat, were linked to a lower risk of CT; while, high consumption of starchy foods, seafood, western standards, rich seaweed, processed meats, instant foods, and fast food has increased the risk of CT,
Additionally, a priori pattern, a diet with higher inflammatory potential was positively associated with thyroid cancer risk. It is possible to see important connections between diet, environment, metabolism and thyroid carcinogenesis, but more robust and clarifying studies with fewer confounding variables and more uniform sample size are required for a deeper understanding of these pathways.
Ethics and dissemination: It is not necessary to acquire ethical approval, this study will be a review of the published data.
Prospero Registration number: International Prospective Register of Systematic Reviews (PROSPERO) CRD 42023463802.