Banca de DEFESA: CIJARA LEONICE DE FREITAS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : CIJARA LEONICE DE FREITAS
DATE: 27/02/2025
TIME: 14:00
LOCAL: REMOTA - https://meet.google.com/yae-gcxa-frk
TITLE:

SIDE EFFECTS OF COVID-19 AND DENGUE VACCINES IN PEDIATRIC PATIENTS

KEY WORDS:

Vaccine, COVID 19 Vaccines, Pediatrics, SARS-CoV-2 Virus

PAGES: 92
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Abstract

Objective:
This study evaluates the adverse events of pediatric vaccines, focusing on COVID-19 and dengue vaccines, and examines their correlation with different doses. Understanding the safety profiles of these vaccines is crucial for public health, particularly in increasing adherence and mitigating disease burden.

Methods:
Following PRISMA guidelines, systematic reviews and meta-analyses were conducted using data from multiple sources, including MEDLINE/PubMed, Web of Science, and Cochrane. Randomized clinical trials on children aged 0 to 17 years were included. The risk of bias was assessed using Cochrane tools, and statistical analyses were performed using RevMan Web and GRADE methodology.

Results:

COVID-19 Vaccines: Among the 19 studies analyzed, vaccinated children showed increased risks of tenderness and axillary disease after the first dose of protein subunit vaccines and swelling after the first dose of mRNA vaccines. Adenovirus vector vaccines were linked to significant local pain after the second dose. Systemic effects such as fever, myalgia, vomiting, and chills were more common with the first mRNA dose, while irritability and crying were prevalent after the second. Febrile events increased with inactivated and adenovirus vaccines. The third dose followed similar adverse event trends.

Dengue Vaccines: In a meta-analysis covering 88,350 participants across 20 studies, TAK-003 was associated with injection site pain, while CYD-TDV presented more frequent local and systemic reactions, including erythema, edema, headache, myalgia, and fever. The rate of serious adverse events varied, but no causal relationship with vaccination was established. Reactogenicity tended to decrease with subsequent doses, indicating an adaptive immune response.

Conclusions:
Both COVID-19 and dengue vaccines demonstrated acceptable safety profiles, with adverse effects being mostly mild, transient, and dose-dependent. While reactogenicity was observed, particularly after initial doses, the benefits of vaccination outweigh potential risks, reinforcing the importance of immunization in disease prevention and community protection. Continued post-marketing surveillance remains essential for monitoring long-term effects and improving vaccine adherence.

 

COMMITTEE MEMBERS:
Presidente - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Externa ao Programa - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS - nullExterno à Instituição - JOSÉ ELEUTÉRIO JÚNIOR - UFC
Externo à Instituição - JOSÉ MANUEL PÉREZ MÁRMOL - UGR - Univer
Externa ao Programa - 2786809 - MARIA THEREZA ALBUQUERQUE BARBOSA CABRAL MICUSSI - null