Banca de QUALIFICAÇÃO: MARCYO CÂMARA DA SILVA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : MARCYO CÂMARA DA SILVA
DATE: 03/02/2026
TIME: 09:00
LOCAL: Remota - https://meet.google.com/qkd-iizb-cop
TITLE:

INDEPENDENT AND JOINT ASSOCIATIONS OF CARDIORESPIRATORY FITNESS AND LOWER-LIMB MUSCLE STRENGTH WITH MAJOR ADVERSE CARDIOVASCULAR EVENTS IN OLDER ADULTS: A LONGITUDINAL STUDY

KEY WORDS:

Older adults, cardiorespiratory fitness, lower-limb muscle strength, major adverse cardiovascular events

PAGES: 20
BIG AREA: Ciências da Saúde
AREA: Educação Física
SUMMARY:

Abstract

Objective: To investigate the independent and joint associations of cardiorespiratory fitness (CRF) and lower-limb muscle strength (LLMS) with major adverse cardiovascular events (MACEs) in older adults.

Methods: This prospective cohort study included community-dwelling older adults aged 60-80 years without diagnosed cardiovascular diseases. CRF and LLMS were the six-minute walk test and the 30-second chair stand test, respectively. Low CRF and LLMS were defined as the lowest quartile, stratified by sex. MACEs were defined as a composite score that included acute myocardial infarction, stroke, and all-cause mortality. Cox proportional hazards regression models adjusted for confounders were used for data analysis. For the independent association analysis, CRF and LLMS were mutually adjusted in the final models. For the joint association analysis, participants were categorized into four groups: i) normal CRF and LLMS (reference); ii) normal CRF and low LLMS; iii) low CRF and normal LLMS; iv) low CRF and LLMS.

Results: A total of 234 participants (mean age: 67.0 ± 5.2 years; 73.1% females) were included in the final analysis. Over a mean follow-up of 5.0 ± 0.8 years, 34 MACEs were recorded. In the independent analysis, low CRF was associated with a higher risk for MACES (HR 2.63; 95% CI: 1.09-6.37), even after adjusting for LLMS. No significant association was observed between low LLMS and MACEs (p > 0.05). In the joint analysis, participants with combined low CRF and LLMS had a higher risk for MACES (HR 3.87; 95% CI: 1.40-10.71). No significant associations were observed for low CRF or LLMS alone (p > 0.05).

Conclusions: Combined low CRF and LLMS were strongly associated with incident MACEs in community-dwelling older adults. These findings suggest that assessing both CRF and LLMS can be clinically useful for identifying older adults at greater risk of MACEs.

COMMITTEE MEMBERS:
Externo ao Programa - 1460020 - ALVARO CAMPOS CAVALCANTI MACIEL - nullPresidente - 2682821 - EDUARDO CALDAS COSTA
Externo ao Programa - ***.425.760-** - FELIPE VOGT CUREAU - UFRN