Banca de QUALIFICAÇÃO: ALINE ALVES SOARES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ALINE ALVES SOARES
DATE: 16/10/2024
TIME: 09:00
LOCAL: REMOTA - HTTPS://MEET.GOOGLE.COM/FQJ-ZACG-BSG
TITLE:

Zinc and thyroid cancer: A systematic review and meta-analysis protocol.

KEY WORDS:

systematic review; meta-analysis; zinc, trace elements; thyroid neoplasms.

PAGES: 9
BIG AREA: Ciências da Saúde
AREA: Medicina
SUMMARY:

Introduction

The thyroid cancer has the ninth larger incidence of cancer in the world. Investigations

related to the exposure to metals have become important due to the sensibility of the thyroid gland to them. Studies reveal that carcinogenic progressions are associated to the deficiency of the essential trace elements. In this context, the zinc is highlighted, essential for the metabolism of the thyroidal hormone and has a potential relation with the pathogenesis of the thyroid cancer. The objective of this systematic review and meta-analysis is to evaluate the low serum zinc as a risk factor for thyroid cancer in adults.

Methods and analysis

PubMed/MEDLINE, Scopus, Embase and LILACS databases will be searched for observational studies investigating the low serum zinc as a risk factor for thyroid cancer in adults. No language or publication period restrictions will be imposed. The primary outcome will be that the low serum zinc is a risk factor for thyroid cancer. Three independent reviewers will select the studies and extract data from the original publications. The risk-of-bias will be assessed by using the Newcastle-Ottawa Quality Assessment Scale (NOS). Data synthesis will be performed using the R software (V.4.3.1) and to assess heterogeneity, we will compute the I2 statistic and the results will be based on either random-effects or fixed-effects models, depending on the heterogeneity. The Grading of Recommendations, Development, and Evaluation (GRADE) system will be used to evaluate the reliability and quality of evidence.

Prospero registration number

International Prospective Register of Systematic Reviews (PROSPERO) CRD42023463747

COMMITTEE MEMBERS:
Presidente - 2495705 - GRASIELA PIUVEZAM
Interno - ***.582.811-** - JOSE BRANDAO NETO - UFRN
Externa ao Programa - 2306763 - KARINE CAVALCANTI MAURICIO DE SENA EVANGELISTA - UFRNExterna ao Programa - 2549958 - LUCIA LEITE LAIS - UFRNExterna ao Programa - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES - UFRN