Banca de DEFESA: MARIA SANTANA DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MARIA SANTANA DA SILVA
DATE: 30/01/2025
TIME: 09:00
LOCAL: Videoconferência
TITLE:

EVALUATION OF TRAZODONE EFFECTS ON REPRODUCTIVE PARAMETERS AND EPIDIDYMAL DUCT CONTRACTION IN RATS

KEY WORDS:

Trazodone, reproductive parameters, testis, epididymis.

PAGES: 80
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUMMARY:

Trazodone is an antidepressant widely used by the male population. However, the effects of this drug on male reproductive health are not yet fully understood. Therefore, this study aims to evaluate the effects of trazodone on epididymal duct contraction and various reproductive parameters in rats. Adult Wistar rats were orally treated for 21 days with saline (control) or trazodone at doses of 10 mg/kg and 20 mg/kg. After the treatment period, the animals were euthanized, reproductive organs were weighed, and the testis and epididymis were isolated for sperm parameter analysis and assessment of the contraction of the distal cauda epididymal duct. In silico studies were also conducted to predict molecular targets related to the effects of trazodone on the male reproductive tract. We observed that trazodone has anti-reproductive effects in rats, characterized by damage to testicular tissue, reduced sperm production, as well as decreased quantity and quality of sperm collected from the cauda epididymis. The contraction of the isolated distal cauda epididymal duct was also affected by in vivo and in vitro trazodone treatment, indicating possible alterations during the emission phase of ejaculation. Additionally, both trazodone and its active metabolite m-CPP showed in silico predictors suggesting nonspecific interactions with pharmacological targets, which may contribute to an unfavorable reproductive toxicological profile. In conclusion, trazodone exhibited significant anti-reproductive effects that may impair male fertility.

COMMITTEE MEMBERS:
Presidente - 2412258 - EDILSON DANTAS DA SILVA JUNIOR
Externa ao Programa - 1645202 - ELAINE CRISTINA GAVIOLI - UFRNExterna à Instituição - MIRIAM DAS DORES MENDES FONSECA