Banca de DEFESA: BYANCA RODRIGUES CARNEIRO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : BYANCA RODRIGUES CARNEIRO
DATE: 26/02/2026
TIME: 15:30
LOCAL: Sala de Aulas GEP/MEJC
TITLE:

Evaluation of vitamin E supplementation in pregnant women

KEY WORDS:

Pregnancy; Preeclampsia; Alpha-tocopherol; Serum Levels; Systematic Review; Clinical Trial.

PAGES: 116
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Vitamin E is a fat-soluble antioxidant essential for maternal–fetal protection against oxidative stress and has been widely investigated in inflammatory conditions such as preeclampsia (PE). In this context, this study evaluated the impact of vitamin E supplementation in pregnant women through two study designs: (1) a systematic review (SR) investigating the effects of supplementation on the mother–child dyad, and (2) a randomized controlled trial (RCT) involving pregnant women with severe PE, aiming to analyze its impact on vitamin E nutritional status. The systematic review (SR) followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, with the protocol registered in PROSPERO (CRD42024529048). Randomized controlled trials (RCTs) were identified from PubMed, Scopus, Web of Science, EMBASE, LILACS, and the Cochrane Library. Study selection, data extraction, and risk-of-bias assessment were conducted independently using the Cochrane Risk of Bias 2.0 tool. Statistical analyses were performed using RevMan software (version 5.4), and the quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. After screening 1,212 studies, six were included. Vitamin E supplementation significantly increased serum alpha-tocopherol (α-TOH) concentrations (SMD = 4.89; 95% CI: 2.89–6.89; p < 0.001), with no effects on gestational age (SMD = 0.04 weeks; 95% CI: −0.03 to 0.11; I2 = 0%; p = 0.29) or birth weight (SMD = −0.02 g; 95% CI: −0.09 to 0.04; I2 = 62%; p = 0.49). The included studies showed a low risk of bias and evidence of low to moderate certainty. The double-blind, placebo-controlled RCT was approved by the Research Ethics Committee (approval no. 6.985.999) and registered in the Brazilian Registry of Clinical Trials (RBR-99h2qmf). Pregnant women with severe PE were randomized to receive either supplementation (400 IU of dl-α-TOH) or placebo (soybean oil) and were followed until the immediate postpartum period. Socioeconomic, obstetric, anthropometric, neonatal, and dietary intake data were collected, along with blood samples at two time points: baseline and immediate postpartum. Serum α-TOH concentrations were determined by ultra-high- performance liquid chromatography, with deficiency defined as values ≤ 30 μmol/L. Data were analyzed using the Statistical Package for the Social Sciences. Descriptive analyses and statistical tests were conducted according to data distribution. Correlations were assessed using Pearson’s or Spearman’s tests, and linear regression models were applied in the intervention group, adopting p < 0.05. Forty-two pregnant women were randomized, with 22 allocated to the intervention group and 20 to the placebo group. All participants presented low mean baseline serum vitamin E levels (4.68 ± 2.12 μmol/L) and inadequate dietary intake (6.06 ± 2.49 mg/day). Supplementation resulted in a significant increase in serum α-tocopherol concentrations in the intervention group (4.29 ± 2.06 vs. 31.70 ± 14.66 μmol/L; p = 0.001), with no association with maternal or neonatal variables. Vitamin E supplementation increased serum α-TOH levels and corrected maternal deficiency; however, it did not result in clinically significant benefits in maternal–infant outcomes, indicating the need for longitudinal studies.

COMMITTEE MEMBERS:
Externa à Instituição - CARLA SORAYA COSTA MAIA - UECE
Externa ao Programa - 1837366 - DANIELLE SOARES BEZERRA - nullPresidente - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES