Banca de DEFESA: ESTHER ARTUANNE FIGUEREDO DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ESTHER ARTUANNE FIGUEREDO DA SILVA
DATE: 27/02/2026
TIME: 10:00
LOCAL: Sala de Aulas GEP/MEJC
TITLE:

Maternal morbidity burden and clinical outcomes in premature infants admitted to a neonatal intensive care unit.

 

KEY WORDS:

Pregnancy; Pregnancy Complications; Premature Newborn; Diseases of the Premature Infant.

 

PAGES: 64
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

It is known that the occurrence of maternal clinical conditions during pregnancy is a determining factor for premature birth, directly impacting fetal development. Preterm newborns (PTNBs) exposed to adverse contexts are more vulnerable to complications such as necrotizing enterocolitis (NEC), bronchopulmonary dysplasia (BPD), and extrauterine growth restriction (EUG), which can significantly compromise growth and development and trigger neonatal death. Despite the clinical relevance and prognostic potential of these morbidities, evidence exploring the relationship between the burden of maternal morbidities and the evolution of premature infants in the neonatal intensive care unit (NICU) is still scarce. Therefore, the objective of this study is to evaluate the relationship between the burden of maternal morbidities and the main clinical complications in PTNBs admitted to the NICU. This research was considered a prospective cohort study, including premature newborns admitted to a public maternity hospital and their mothers, from October 2021 to November 2023. Maternal data (age, morbidities during pregnancy) and data on the preterm newborn during their stay in the NICU (gestational age at birth, birth weight and weight at discharge, days of parenteral nutrition use, length of stay, and clinical outcomes) were collected. Data were analyzed using normality tests (Shapiro-Wilk) and association tests (Chi-square and Fisher's exact test), as well as non-parametric tests (Mann-Whitney and Kruskal-Wallis) for comparisons between groups, considering p<0.05 as the significance level. 160 mother-child pairs were included; the majority of postpartum women (72.5%) presented at least one morbidity, the most frequent being hypertensive syndromes of pregnancy (HSP) (42.5%) and urinary tract infection. (UTI) (28.7%). Among preterm newborns, we identified that 61.3% had more severe degrees of prematurity, 48% had a birth weight below 1500g, and 74.8% had adequate weight for corrected gestational age at NICU discharge. The prevalences of NEC were 6%, BPD 14%, UGIB 25.9%, and death 9.4%. No statistically significant association was found between the burden of maternal morbidities and the clinical outcomes evaluated. Furthermore, we found a significant association between maternal age and the presence and burden of morbidities (p < 0.001), with women aged 35 years or older showing a higher prevalence (91.5%) and a higher frequency of morbidity burden (40.4%). Final considerations: Despite the higher prevalence of maternal morbidities in pregnant women of advanced age (≥35 years), no significant association was found with neonatal outcomes. However, UTI was associated with shorter hospital stays and a lower incidence of bronchopulmonary dysplasia. This finding highlights the complexity of the relationship between maternal and neonatal outcomes, justifying further research.

COMMITTEE MEMBERS:
Externa à Instituição - CINTHIA KARLA RODRIGUES DO MONTE GUEDES
Externa à Instituição - ANNA CHRISTINA DO NASCIMENTO GRANJEIRO BARRETO - EBSERH
Interno - 2328351 - GUSTAVO MAFALDO SOARES
Presidente - 2315640 - MARCIA MARILIA GOMES DANTAS LOPES