Banca de DEFESA: JANAINA CAVALCANTI COSTA DE OLIVEIRA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : JANAINA CAVALCANTI COSTA DE OLIVEIRA
DATE: 19/02/2026
TIME: 14:00
LOCAL: Sala de Aulas GEP/MEJC
TITLE:

IMPACT OF NUTRITIONAL THERAPY WITH HUMAN MILK ON GROWTH OUTCOMES AND GASTROINTESTINAL COMPLICATIONS IN PREMATURE NEWBORNS.

KEY WORDS:

Breast milk, Human milk banks, Postnatal growth, Premature newborn

PAGES: 40
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Human milk is also the recommended food for preterm newborns (gestational age below 37 weeks), as it is a complex fluid containing several bioactive factors, in addition to specific macro- and micronutrients appropriate to each stage of lactation. For low birth weight preterm newborns (LBW-PTN, below 1,800 g) it is even more relevant, given its effect on reducing severe morbidities that affect them due to the physiological fragility resulting from premature birth. Colostrum milk is recommended as an early oropharyngeal exposure for these newborns, but data in the literature are still scarce regarding the impact of nutritional therapy with donated human milk on nutritional outcomes of LBW-PTN. Thus, the aim of this study was to analyze the effect of therapy with donated human milk (colostrum + hypercaloric human milk) on growth outcomes and gastrointestinal complications in LBW- PTN admitted to the neonatal intensive care unit (NICU). To this end, we used two methodological models: Study 1, a systematic review and meta- analysis (CRD420251056373) on the effect of an exclusive human milk diet versus the use of human milk fortifiers and infant formulas based on bovine protein on the development of gastrointestinal complications in preterm infants. The review showed that feeding tolerance was similar between exclusive human milk diets and those supplemented with bovine milk-derived products. The meta-analysis for the outcome necrotizing enterocolitis (281 versus 214 participants) did not show a significant difference between groups (OR = 1.47; 95% CI: 0.80–2.72); however, the studies presented moderate heterogeneity and only two compared with the use of infant formula. Study 2 was a randomized controlled clinical trial with 94 LBW-PTN enrolled up to 96 hours postpartum or after 48 hours of initiation of enteral feeding, admitted to the NICU of a high-risk referral maternity hospital. After eligibility criteria, participants were randomly allocated in a 1:1 ratio to the control group (standard nutritional therapy with pasteurized human milk of transition or mature type + expressed mother’s own milk) and the intervention group (nutritional therapy with pasteurized colostrum-type human milk until reaching 100 ml/kg/day, followed by pasteurized hypercaloric milk + expressed mother’s own milk). LBW-PTN received the intervention until discharge from the NICU or until a change in specific diet prescription by the healthcare team. Data related to volume and type of pasteurized milk ingested, type of prescribed diet, anthropometric measurements, and duration of intervention were collected throughout the follow-up period. The primary clinical outcomes were weight-for-age gain velocity (g/kg/day and change in weight-for-age Z- score) from birth to the end of the intervention. Secondary outcomes were time to regain birth weight (days), length-for-age velocity (Z-score), presence of growth failure, extrauterine growth restriction, and length of stay in the NICU. Pearson’s chi-square test was used to analyze the association between categorical variables. The effect size for significant associations was assessed by calculating prevalence ratios (PR) and their 95% confidence intervals (95% CI). The clinical and anthropometric characterization of the groups showed similar profiles between them; however, the outcome related to weight gain velocity (g/kg/day) was higher in the intervention group (p < 0.006), demonstrating the positive impact of nutritional therapy with pasteurized colostrum-type and hypercaloric human milk on the growth of LBW-PTN.

COMMITTEE MEMBERS:
Presidente - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES
Externa à Instituição - MAYARA SANTA ROSA LIMA - UFRB
Externa ao Programa - 4220250 - NIVIA MARIA RODRIGUES ARRAIS - null