Banca de DEFESA: PAULA LIMA GALVÃO GOMES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : PAULA LIMA GALVÃO GOMES
DATE: 25/02/2025
TIME: 09:00
LOCAL: Sala de Aulas II GEP/MEJC
TITLE:

Association of SARS-CoV-2 infection with retinol status in pregnant women: A case-control study

 

KEY WORDS:

COVID-19, Pregnancy, Vitamin A, Infection, Inflammation.

PAGES: 56
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

There is evidence that situations of infection and inflammation are related to vitamin A deficiency (VAD), especially in children and pregnant women. Therefore, the objective of this research was to evaluate the influence of SARS-CoV-2 (COVID-19) infection on the vitamin A (retinol) status of pregnant women treated at a referral hospital for high-risk pregnancies. This is a case-control study comprising 60 pregnant women hospitalized with symptoms of COVID-19 between February 2021 and February 2022, and grouped according to the diagnosis of infection (with COVID-19, n=29 and symptomatic without COVID -19, n= 31). For comparative purposes, 63 low-risk pregnant women analyzed in a period prior to the emergence of COVID-19 in the same maternity hospital were included. The diagnosis of COVID-19 was made using RT-PCR for SARS-CoV-2 in a combined nasopharyngeal swab. Data collection comprised socioeconomic, demographic, clinical, biochemical information and retinol analysis in the women's serum. Retinol was analyzed by Ultra Performance Liquid Chromatography and VAD was determined when serum retinol <20 μg/dL. For statistical analysis, JASP and IBM SPSS software were used. The average age of pregnant women was 26 years old, practically half of them lived in Natal-RN (51.2%), and only two pregnant women had VAD (1.80%). The mean serum retinol was higher in pregnant women diagnosed with COVID-19 (54.50 μg/dL) than in the other groups (p<0.001). Linear regression analysis adjusted for gestational age at birth confirmed the positive association between retinol levels and the presence of COVID-19 (β= 17.22, 95%CI= 9.670 - 24.77, p<0.001). The data demonstrated that the presence of SARS-CoV-2 infection appears to maintain circulating serum retinol levels, which differs from data in the literature in situations of infection with other viruses and at other stages of life. Given this result and the limitations of the literature on retinol metabolism in pregnant women, it is noteworthy that this is the first study that verified the influence of COVID-19 on retinol in pregnant women, and it is therefore necessary to verify the behavior of retinol in this population during COVID-19, and whether serum retinol is the most appropriate biomarker in this situation. This study was approved by the Research Ethics Committee of the Hospital Universitário Onofre Lopes.

COMMITTEE MEMBERS:
Externa ao Programa - 1755394 - JULIANA FERNANDES DOS SANTOS DAMETTO - nullPresidente - 2578592 - KARLA DANIELLY DA SILVA RIBEIRO RODRIGUES
Externa à Instituição - MAYARA SANTA ROSA LIMA - UFRB