Impact of ultra-processed food consumption on maternal-child weight outcomes among women with Gestational Diabetes Mellitus: A cohort study.
Pregnancy, High-Risk; Maternal Nutrition; Food Consumption; Gestational Weight Gain; Birth Weigh.
Although the literature presents the negative health consequences of consuming ultra-processed foods (UPF) in relation to adiposity and the development of chronic non-communicable diseases, there is still a scarcity of studies evaluating the impact of this consumption during the gestational period, especially on obstetric and perinatal outcomes in women with high-risk pregnancies. The aim of this study was to assess the impact of UPF
consumption on weight outcomes in the mother-child binomial of women with Gestational Diabetes Mellitus (GDM). This is an observational, prospective cohort study of 140 women diagnosed with GDM and their newborns, treated at the Januario Cicco Maternity School in Natal, Brazil. Data collection included sociodemographic characteristics, clinical and obstetric data, anthropometric data and food consumption, collected at three points in time: the first from the second gestational trimester (T1), the second in the third
trimester (T2) and the last in the immediate postpartum period (T3). Food consumption was obtained using a 24-hour recall and food was categorized according to the Nova classification. Weight outcomes in the mother-child binomial were assessed by gestational weight gain (GWG) at T1 and T2, total GWG (T3) and assessment of birth weight for gestational age. The mother- child binomials were grouped by tertiles of UPF grams and, secondarily, by tertiles of UPF calorie intake. The results of the multiple linear regression models and generalized linear models with Poisson adjustment were analysed to ascertain the association between UPF consumption in grams and maternal and infant weight outcomes, with adjustments for confounding variables. The significance level assigned to the tests used was p<0.05. Energy consumption was 1960.72 (±460.73) calories, with a PSA contribution of 17.95% (95% CI = 16.24 - 19.66). Most of the women started pregnancy obese (57.10%). The BW at T1 was 4.36 (±5.97) kg and at T2 4.44 (±7.27) kg, showing a rapid cumulative gain in 57.10% and 47.60% of the pregnant women, respectively. The total GPG (T3) was 6.86 (±6.78), and they were classified as having a high GPG (50.70%). As for the newborns, the average birth weight was 3133.17 (±466.29), with the majority being classified as having an adequate birth weight (91.10%). The multiple linear regression models showed a positive relationship between a higher share of UPF in grams in the pregnant women's diet and cumulative and total FGW (β = 0.014; p = 0.002 and β = 0.015; p = -0.023, at T1 and T3, respectively). While the generalized linear models with Poisson adjustment showed that when grouped in the highest tertile of UPF consumption in grams, there was an increase of 3.424 in the risk of high birth weight (RR = 3.424; 95%CI = 1.068 - 10.974; p = 0.038). In conclusion, the results of this study were sensitive to infer that the consumption of UPF has an impact on maternal and infant weight outcomes in women with GDM, and it is important to discourage a diet composed of UPF at this stage.