Banca de QUALIFICAÇÃO: JÉSSIKA ALINE DO NASCIMENTO MEDEIROS
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.STUDENT : JÉSSIKA ALINE DO NASCIMENTO MEDEIROS
DATE: 29/05/2022
TIME: 14:00
LOCAL: Sala de reunião da GEP, na Maternidade Escola Januário Cicco/UFRN
TITLE:
Characterization of Th17, Th1 and Th2 axis cytokine profile and gene polymorphism in patients with cervical cancer.
KEY WORDS:
- Cervical cancer, polymorphism, Th1, Th2 and Th17 profile cytokines
PAGES: 20
BIG AREA: Ciências da Saúde
AREA: Farmácia
SUMMARY:
Cervical cancer (CCU) is a public health problem that affects many women
around the world and its etiology and pathogenesis are intrinsically linked to
HPV, representing the fourth cause of death among women. Estimates report
that about 80% of sexually active women will acquire an infection in their
lifetime. It is known that the host's immune system, in most cases, is able to
eliminate the HPV virus, but in some cases the patient will develop a persistent
infection, which will culminate in the emergence of cervical cancer. Considering
the importance of the immune system in this process, it is necessary to
understand the role of the subpopulations involved in this process of modulating
the immune system. Therefore, evaluating the Th17, Th1 and Th2 pattern via
cytokine quantification and associating the gene polymorphism of the IL-17A/IL-
17RA axis is the objective of the present study. To date, 27 samples of genomic
DNA extracted from peripheral blood were evaluated to perform the
polymorphism of the IL-17A cytokine axis and its receptor, and 167 samples
were analyzed for IL-17A and 183 samples for IL-17RA. In the total of 428
samples, they were stratified in 104 (24 %) patients with cervical cancer (CC),
125 (29 %) patients with high-grade lesions, 86 (20 %) patients with low-grade
lesions, 104 ( 24%) patients were NILM, and 9 patients (3%) had indeterminate
lesions.
BANKING MEMBERS:
Interna - 1199080 - ANA KATHERINE DA SILVEIRA GONCALVES DE OLIVEIRA
Externa à Instituição - ANA PAULA FERREIRA COSTA
Presidente - 3313589 - JANAINA CRISTIANA DE OLIVEIRA CRISPIM FREITAS