Banca de QUALIFICAÇÃO: JESSIKA GUILHERME DE ALMEIDA GONCALVES

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : JESSIKA GUILHERME DE ALMEIDA GONCALVES
DATE: 05/03/2026
TIME: 14:30
LOCAL: SALA DE AULA DA PATOLOGIA ORAL
TITLE:

Study of the interaction between immunological control proteins (PD-1 and PD-L1) and bone metabolism in odontogenic cysts

KEY WORDS:

Immunohistochemistry. Immune Response Evasion. Odontogenic cysts. Bone remodeling

PAGES: 41
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Odontogenic cysts constitute a heterogeneous group of lesions affecting the gnathic bones, exhibiting distinct biological behaviors and the ability to interfere with the physiological balance between bone resorption and apposition processes, particularly through the activation of osteoclastogenesis. Although the cellular and molecular mechanisms underlying these processes have not yet been fully elucidated, the expression of inhibitory or stimulatory factors involved in bone resorption may influence the dynamics and behavior of these lesions. In this context, several biomarkers have been investigated, notably the immunomodulatory PD-1/PD-L1 axis and the classical bone resorption regulatory system RANK/RANKL/OPG, both of which play a central role in the modulation of osteoclastogenesis and bone remodeling. An integrated analysis of these markers may contribute to a better understanding of the interactions between the immune system and bone metabolism, as well as to the distinction of aggressiveness patterns among different types of odontogenic cysts. Therefore, the aim of this study is to analyze and compare the immunohistochemical expression of PD-1/PD-L1 and RANK/RANKL/OPG in the main cysts affecting the maxillofacial region (radicular cyst, residual cyst, dentigerous cyst, and odontogenic keratocyst), diagnosed at the Laboratory of Anatomic Pathology and Cytopathology of the Department of Dentistry at the Federal University of Rio Grande do Norte (UFRN). A semiquantitative analysis of the distribution of immunolabeled epithelial and mesenchymal cells will be performed, followed by statistical and inferential analysis (p ≤ 0.05), aiming to contribute to a better understanding of the role of these markers in the biological behavior of these lesions, with potential implications for biological risk stratification and for expanding the foundation of future diagnostic and prognostic approaches.

COMMITTEE MEMBERS:
Presidente - 350484 - ROSEANA DE ALMEIDA FREITAS
Interna - 350485 - HEBEL CAVALCANTI GALVAO
Interna - 1298808 - MARCIA CRISTINA DA COSTA MIGUEL