Banca de DEFESA: MIRELA MARTINA OLIVEIRA DE MOURA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : MIRELA MARTINA OLIVEIRA DE MOURA
DATE: 14/10/2025
TIME: 14:00
LOCAL: DEPARTAMENTO DE ODONTOLOGIA - AUDITÓRIO
TITLE:

EFFECT OF MELATONIN USE ON ORTHODONTIC TOOTH MOVEMENT IN RATS

KEY WORDS:

Orthodontics; Melatonin; Tooth Movement Techniques; Wistar Rats.

PAGES: 70
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUMMARY:

Introduction: Orthodontic tooth movement involves a process of bone remodeling,
which may be influenced by external factors. Melatonin (MT) appears capable of interfering
with bone metabolism and, consequently, with the bone remodeling process. Objective: To
evaluate the effect of melatonin on orthodontic tooth movement (OTM) in rats. Methods: This
was an experimental, in vivo, controlled, and randomized study with descriptive and
inferential approaches. The sample consisted of 24 healthy male Wistar rats (Rattus
norvegicus albinus), aged 8–12 weeks, subjected to continuous orthodontic tooth movement
of the upper left first permanent molars for 21 days. The rats were randomly divided into two
groups: Control Group (CG) – rats subjected only to orthodontic movement and daily water
intake (n = 12); and Melatonin Experimental Group (MEG) – rats subjected to orthodontic
movement and daily melatonin administration (n = 12). The amount of OTM was assessed
using micro-computed tomography (micro-CT). Periodontal ligament aspects were described
by morphological analysis. Statistical tests were performed using SPSS software version 20.0
for Windows, with a significance level of 5% (p < 0.05). Results: Micro-CT analysis, which
evaluated linear parameters (mesial and vertical orthodontic tooth movement, and
periodontal ligament thickness) and volumetric parameters (bone volume, porosity, and
trabecular number), showed no statistically significant differences between groups (p > 0.05).
Histological analysis revealed greater intensity of periodontal phenomena on the orthodontic
movement side compared with the non-movement side (mesial/pressure side, control group:
p = 0.0313; distal/tension side, control group: p = 0.0313; mesial/pressure side, melatonin
group: p = 0.0313), except for the melatonin distal/tension side (p = 0.125). On the other
hand, no statistically significant differences in this parameter were observed when comparing
tension or pressure regions on the orthodontic movement side between groups (tension side:
p > 0.9999; pressure side: p > 0.2381). Conclusion: The study suggests that melatonin does
not affect bone quality in a way that facilitates or hinders orthodontic tooth movement in the
experimental model.

 

COMMITTEE MEMBERS:
Presidente - 1958729 - RUTHINEIA DIOGENES ALVES UCHOA LINS
Interna - 2374605 - AURIGENA ANTUNES DE ARAUJO
Externo à Instituição - ALEXANDRE ANTONIO RIBEIRO