DEVELOPMENT OF A PLANT-DERIVED NANOSTRUCTURED ANTIMICROBIAL COMPLEX FOR THE FUNCTIONALIZATION OF DIRECT RESTORATIVE MATERIALS
montmorillonite, gallic acid, dental resin, dental adhesive, in vitro techniques.
Background: Caries lesions adjacent to direct restorative materials remain a major cause of treatment failure, driving the development of materials capable of gradually releasing antimicrobial agents. In this context, incorporating controlled-release systems for antimicrobial agents, particularly phytotherapeutics, into direct restorative materials may offer a viable solution. Purpose: To develop a controlled-release system for an antimicrobial phytotherapeutic agent using nanoclay and evaluate its effect when incorporated into composite resin and adhesive systems. Methods: Gallic acid will be incorporated into montmorillonite to create the release system, which will subsequently be included in a composite resin and adhesive system. Following the incorporation of this complex into direct restorative materials, analytical techniques, such as scanning electron microscopy, energy-dispersive spectroscopy, and X-ray diffraction, will be performed to confirm the inclusion of gallic acid in the montmorillonite. Subsequently, controlled release tests for gallic acid, antibacterial activity, degree of conversion, surface roughness, hardness, flexural strength, elastic modulus, and dentin bond durability will be performed. Expected results: The restorative materials developed in this study are anticipated to exhibit antibacterial properties through the release of the active agent while maintaining their physical properties. These features could render them promising allies in preventing caries lesions adjacent to composite resin restorations.