Banca de QUALIFICAÇÃO: KATRYNE TARGINO RODRIGUES

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : KATRYNE TARGINO RODRIGUES
DATE: 10/07/2025
TIME: 11:00
LOCAL: Departamento de Odontologia - SALA DE AULA 02
TITLE:

INNOVATIVE FORMULATION OF MUCOADHESIVE TOOTHPASTE WITH PROBIOTIC LACTICASEIBACILLUS CASEI

KEY WORDS:

Periodontitis; Probiotics; Lacticaseibacillus casei;

PAGES: 39
BIG AREA: Ciências da Saúde
AREA: Odontologia
SUBÁREA: Periodontia
SUMMARY:

 

The oral cavity harbors a complex microbiome, usually maintained in dynamic balance, whose disruption can favor the growth of pathogenic microorganisms, leading to periodontal diseases. This microbial dysbiosis may precede the clinical signs of periodontitis, highlighting the importance of preventive strategies. Probiotics, defined by the WHO as live microorganisms that confer health benefits when administered in adequate amounts, have shown potential in controlling the oral microbiota. To be effective in this environment, they must adhere to dental surfaces, produce antimicrobial substances, reduce inflammation, and modulate the immune system. Studies have reported that strains such as Lacticaseibacillus casei are effective as adjuvants in periodontal treatment, with a positive impact on clinical periodontal parameters. In this context, the present study proposes the development of a gel-based toothpaste containing L. casei, aiming to assess its physicochemical properties, stability, and cytocompatibility. The gel will be formulated with chitosan, natrosol, Juá extract, and the probiotic, following strict laboratory protocols. Stability tests will be conducted at different time intervals, along with organoleptic assessments, pH analysis, scanning electron microscopy (SEM), spectroscopy (FTIR-ATR), rheological studies, hemocompatibility, and in vitro cellular cytocompatibility. The probiotic’s viability will be determined by counting viable colony-forming units (CFU/g). Data will be statistically analyzed using ANOVA and non-parametric tests depending on data normality. The goal is to validate the efficacy and safety of an innovative mucoadhesive formulation that enhances the beneficial effects of probiotics in the prevention and control of periodontal diseases, offering an alternative and complementary therapeutic approach to conventional techniques.

COMMITTEE MEMBERS:
Presidente - 2085732 - ANA RAFAELA LUZ DE AQUINO MARTINS
Interna - 2374605 - AURIGENA ANTUNES DE ARAUJO
Interna - 1958729 - RUTHINEIA DIOGENES ALVES UCHOA LINS