Banca de DEFESA: ANNE NATHALIA DE SOUSA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ANNE NATHALIA DE SOUSA SILVA
DATE: 18/12/2021
TIME: 14:00
LOCAL: https://meet.google.com/rir-dytx-jce
TITLE:

OXIDATIVE STRESS, INDOLEAMINE-2,3 DIOXYGENASE ACTIVITY AND BIOCHEMICAL PARAMETERS RELATED TO SUCROSE CONSUMPTION AND WITHDRAWAL IN RAT DIET

KEY WORDS:

Sucrose, IDO, Oxidative stress, biochemical parameters, mental health

PAGES: 71
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUBÁREA: Neuropsicofarmacologia
SUMMARY:

Sucrose is the most commonly used sugar in diets. Excessive sugar consumption is associated with liver disorders and metabolic syndrome due to sucrose metabolism. Furthermore, sucrose withdrawal has been associated with the development of mental disorders such as anxiety disorder and depressive disorder. Alterations in oxidative stress and expression of indoleamine-2,3dioxygenase (IDO), an enzyme responsible for shifting tryptophan metabolism from serotonin synthesis to the kynurenine pathway, are reported in mental disorders and metabolic syndromes. Thus, this work aims to investigate metabolic changes in oxidative stress, IDO activity and biochemical parameters related to metabolic syndrome and anxiety and depression disorders, in serum, prefrontal cortex (PFC), hippocampus and striatum of Wistar rats subjected to sucrose exposure and withdrawal. The two-bottle sucrose choice paradigm was adopted, the animals had access to one bottle of water and the other available according to the group, control (water), short-term withdrawal (unlimited 5% sucrose for 16 days and withdrawal for 3-4 days), long-term withdrawal (unlimited 5% sucrose for 16 days and withdrawal for 23-24 days) and continuous sucrose (unlimited 5% sucrose for 19-20 days). Serum biochemical parameters, IDO enzyme activity and levels of oxidative stress from protein carbonyl and lipid peroxidation in the prefrontal cortex, hippocampus and striatum were analyzed. The results showed that 5% sucrose consumption is able to alter lipid metabolism, but the withdrawal for 3 days reverses changes related to triglyceride levels. The 5% sucrose consumption or withdrawal did not show significant differences in the oxidative stress parameters or the IDO enzyme activity, in the analyzed tissues, compared to the control group, although a trend of increased oxidative stress was observed in sucrose withdrawal groups. It was also possible to observe the consumption and preference of sucrose by age, pointing to adolescence as the phase of greatest consumption.

BANKING MEMBERS:
Externo ao Programa - 2412258 - EDILSON DANTAS DA SILVA JUNIOR
Externa à Instituição - JULIANA FÉLIX DA SILVA - UNIFACEX
Presidente - 1720860 - VANESSA DE PAULA SOARES RACHETTI