Banca de QUALIFICAÇÃO: ANNE NATHALIA DE SOUSA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : ANNE NATHALIA DE SOUSA SILVA
DATE: 21/10/2021
TIME: 08:30
LOCAL: Remoto
TITLE:

BIOCHEMICAL PARAMETERS RELATED TO THE CONSUMPTION AND WITHDRAWAL OF SUCROSE

KEY WORDS:

Anxiety, Depression, sucrose, IDO, Oxidative stress, biochemical parameters

PAGES: 64
BIG AREA: Ciências Biológicas
AREA: Farmacologia
SUBÁREA: Neuropsicofarmacologia
SUMMARY:

Sucrose is the most commonly used sugar in diets. Excessive sugar consumption is associated with liver disorders and metabolic syndrome due to sucrose metabolism. Furthermore, sucrose withdrawal has been associated with the development of mental disorders such as anxiety disorder and depressive disorder. Changes in oxidative stress and expression of indoleamine- 2,3 dioxygenase (IDO), an enzyme responsible for shifting tryptophan metabolism from serotonin synthesis to the kynurenine pathway, are reported in mental disorders and metabolic syndromes. Thus, this work aims to investigate metabolic changes in biochemical parameters related to metabolic syndrome and anxiety and depression disorders, in serum, prefrontal cortex (PFC), hippocampus and striatum of Wistar rats subjected to sucrose exposure and withdrawal. The two-bottle sucrose choice paradigm was adopted, the animals had access to one bottle of water and the other available according to the group, control (water), short-term withdrawal (unlimited 5% sucrose for 16 days and withdrawal for 3 or 4 days), long-term withdrawal (unlimited 5% sucrose for 16 days and withdrawal for 23 or 24 days) and continuous sucrose (unlimited 5% sucrose for 19 or 20 days). Serum biochemical parameters, IDO enzyme activity and levels of oxidative stress from protein carbonyl and lipid peroxidation in the prefrontal cortex, hippocampus and striatum were analyzed. The results showed that 5% sucrose consumption is able to alter lipid metabolism, but the withdrawal for 3 days reverses changes related to triglyceride levels. The 5% sucrose consumption or withdrawal did not promote significant differences in the oxidative stress parameters or the IDO enzyme activity, in the analyzed tissues, compared to the control group.  

BANKING MEMBERS:
Presidente - 1720860 - VANESSA DE PAULA SOARES RACHETTI
Externa ao Programa - 2477216 - NAISANDRA BEZERRA DA SILVA FARIAS
Externa à Instituição - ANNA KARYNNA ALVES DE ALENCAR ROCHA