Banca de DEFESA: RENATA SOUZA E SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : RENATA SOUZA E SILVA
DATA : 08/03/2019
HORA: 10:00
LOCAL: Auditório do Programa de Pós-graduação em Biologia estrutural e Funcional
TÍTULO:

EFFECTS OF EXTRACT ALLIUM CEPA L. AND S-METILCYSTEIN IN THE  MORPHOLOGY IN TESTÍCULES OF DIABETIC RATS INDUCED BY ESTREPTOZOTOCIN

PALAVRAS-CHAVES:

Diabetes mellitus, Onion extract, Testicular morphophysiology, Immunohistochemistry

PÁGINAS: 80
GRANDE ÁREA: Ciências Biológicas
ÁREA: Morfologia
SUBÁREA: Histologia
RESUMO:

Diabetes Melitos (DM) is a complex, endocrine and diffuse disease that requires continued medical assistance for glycemic control as well as detection of risk factors. DM is marked by metabolic abnormalities and chronic complications, with infertility being one of the most recently mentioned. This infertility is characterized by reduced testosterone levels and changes in the germinal epithelium of the seminiferous tubules. The use of herbal medicines, in the combat or prevention of some diseases, has been increasing over the years, since it is a low cost alternative and easy to reach for the population. The extract of Allium cepa L. (onion) has already been reported as hypoglycemic and antilipemic. The amino acid extracted from this extract, called Smethylcysteine, presents even more positive results in several studies. The acquisition of new therapies that may aid in the treatment of diabetes is extremely important, since it has a direct impact on the well-being of society. Thus, this work aimed to investigate the morphofunctional, biochemical and morphometric aspects of the testicular tissue of diabetic rats, induced by streptozotocin, treated with extract of A. cepa L. and with the amino acid S-methylcysteine. Male Wistar rats weighing 200-250 g were divided into the following groups: normoglycemic control, diabetic without treatment, diabetic treated with the extract of A. cepa L. (400 mg / kg) and treated diabetic with the amino acid Smethylcysteine (200 mg / kg). DM was induced by streptozotocin (40 mg / kg intraperitoneally) and the treatment was performed by gavage daily for a period of 4 weeks. After euthanasia, the testes were collected for histological analysis of tissue integrity (Hematoxylin and Eosin). Morphometric parameters were analyzed by toluidine blue staining. Immunohistochemical marking was performed to determine the presence of testosterone receptors in the testicular tissue. The onion extract presented positive results as a form of therapy, mainly in the availability of receptors for testosterone. The isolated amino acid was able to present even better results in a generalized way in the improvement of the integrity of the testicular tissue.

MEMBROS DA BANCA:
Externo à Instituição - FERNANDA CAROLINA RIBEIRO DIAS
Presidente - 2477216 - NAISANDRA BEZERRA DA SILVA FARIAS
Externa ao Programa - 2261797 - TIRZAH BRAZ PETTA LAJUS