Banca de DEFESA: NATAN REYGES CASTRO DA PURIFICAÇÃO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : NATAN REYGES CASTRO DA PURIFICAÇÃO
DATA : 29/01/2018
HORA: 09:00
LOCAL: SALA DE REUNIÕES DA PÓS-GRADUAÇÃO
TÍTULO:

Effects of associated treatment with quercetin, glutamine and α-tocopherol on the myocardial morphology of diabetic rats.

PALAVRAS-CHAVES:

Antioxidants; Diabetic cardiomyopathy; Ventricular remodeling.

PÁGINAS: 68
GRANDE ÁREA: Ciências Biológicas
ÁREA: Morfologia
RESUMO:

Diabetic cardiomyopathy (DC) is one of the major causes of morbidity and mortality in diabetic patients, and it can characterized by hypertrophy and cardiac fibrosis. The aims of this study was to analyze the effects of the antioxidant joint treatment quercetin (100mg/kg body weight), 1% glutamine and 1% α-tocopherol in the myocardium of rats with streptozotocin-induced diabetes mellitus (DM-STZ). 20 male rats with 150 days old were subdivided into groups (n = 5): N (normoglycemic); D (diabetic); NT (normoglycemic treated with antioxidants) and; DT (diabetic treated with antioxidants). The results showed reduction of body weight, hyperphagia, polydipsia and maintenance of the hyperglycemic state in the D and DT groups. An increase in the heart weight / final body weight coefficient was observed (HW/FW), indicative of cardiac hypertrophy in D and DT. There was an increase in circulating levels of MPO, MDA, GSH and IL-10 in DT. Increased expression of SOD-1, GPX-1, IL-1β, TGF-1β and deposition of collagen fibers in D. In DT there was increased expression of SOD-1, IL-1β, TGF-1β and FGF-2 and, GPX-1 reduction of collagen fibers deposition. These results indicate that the joint treatment with different antioxidants in rats with DM-STZ stimulated the redox (GSH and SOD-1) and anti-inflammatory (IL-10) pathways, increased the expression of FGF-2 required for remodeling and decreased the collagen fibers compared to untreated diabetic animals, indicating that at least for the myocardium the treatment was beneficial.

MEMBROS DA BANCA:
Externo ao Programa - 2374605 - AURIGENA ANTUNES DE ARAUJO
Externo à Instituição - JACQUELINE NELISIS ZANONI - UEM
Presidente - 1544854 - NAIANNE KELLY CLEBIS