Banca de QUALIFICAÇÃO: KAIO RAMON DE AGUIAR LIMA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
DISCENTE : KAIO RAMON DE AGUIAR LIMA
DATA : 18/12/2017
HORA: 14:00
LOCAL: SALA DA PÓS-GRADUÇÃO BioEF/SALA DE REUNIÕES DO DMOR
TÍTULO:

EFFECT OF L-GLUTAMINE IN THE RATS’s GLOMERULAR MORPHOLOGY WITH WALKER-256 TUMOR.

PALAVRAS-CHAVES:

Cancer; Kidney; Antioxidants; Fibrosis; Morphology.

PÁGINAS: 51
GRANDE ÁREA: Ciências Biológicas
ÁREA: Morfologia
RESUMO:

Cancer is a high quality pathology that encompasses different regions of the body. His indecency has increased every year, for this reason, studies on its effects and also with treatments that seek the best in the quality of life of its carriers have been widely realized. The increase of systemic oxidative stress has been one of the main children found in cancer, even in places where there is no metastasis. This study aimed to analyze the effects of cancer induction by the Walker-256 tumor model, as well as treatment with L-glutamine (2%) on renal morphophysiology. Twenty male Wistar rats were used, distributed in four groups: control (C); tumor carriers of Walker-256 (WT); control treated with 2% L-glutamine (CG) and; Walker-256 tumor carriers treated with 2% L-glutamine (WTG). The results demonstrated that the glomerular density was lower in the WT group. The morphometric findings indicate that they are not separated between a glomerular area between the animals studied. The area of the glomerular tuft was larger in WT while the area of urinary space was smaller in the group than in the other groups. The area of the glomerular mesangium was larger in the WT and WTG than in the C groups, but WTG was smaller than WT. The percentage of the area occupied by extracellular matrix in the glomerular tuft was higher in WT and WTG than in the other groups. A glomerular area occupied by collagen was higher in WT and WTG, being smaller than the treated group. An expression of FGF-2 was greater in group C than in the other groups, being the WT group that offered lower immunostaining. The results indicate that the systemic inflammation promoted by Walker-256 tumor induction from a non-WT group of renal morphophysiology, with a decrease in glomerular number, inhibits glomerular tuft morphometry, mesangium and extracellular matrix, collagen increase and expression of FGF-2, indicative of renal fibrosis and decreased remodeling / tissue recovery. Treatment with Lglutamine 2% no WTG group had borderless protector compared to WT, but with findings still suggestive of glomerular lesions due to inflammation, which will indicate that, probably, a supplementation with a higher concentration of L- glutamine, glutamine virus.

MEMBROS DA BANCA:
Externo à Instituição - CARLOS EDUARDO BEZERRA DE MOURA - UFERSA
Presidente - 1544854 - NAIANNE KELLY CLEBIS
Interno - 2477216 - NAISANDRA BEZERRA DA SILVA FARIAS