Banca de DEFESA: WYLQUI MIKAEL GOMES DE ANDRADE

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : WYLQUI MIKAEL GOMES DE ANDRADE
DATA : 24/07/2017
HORA: 08:00
LOCAL: Auditório do Departamento de Morfologia
TÍTULO:

DISTRIBUTION OF NITRIC OXIDE IN THE SUBCORTICAL TELENCEPHALON OF ROCK CAVY (Kerodon rupestris)

PALAVRAS-CHAVES:

Nitric oxide, Nitric oxide synthase, Telencephalon, Kerodon rupestris.

PÁGINAS: 76
GRANDE ÁREA: Ciências Biológicas
ÁREA: Morfologia
SUBÁREA: Anatomia
RESUMO:

Nitric oxide (NO) is a gaseous molecule that acts as a neurotransmitter, regulating synaptic events and participating in neural functions such as memory and learning. In the nervous system, NO is synthesized by neuronal nitric oxide synthase (nNOS). As a gaseous molecule, NO can diffuse freely trespassing the cells membrane. Because of this NO can act as a retrograde neurotransmitter and is usually treated as a local moderator. NO and nNOS are highly conserved among species and are present in the nervous system of many vertebrates. We performed immunohistochemical anti-nNOS and histochemical for NADPH-diaphorase in order to investigate the distribution of nitrergic cells in the subcortical compartment of the rock cavy (Kerodon rupestris) telencephalon. The data show a heterogeneous distribution of neurons immunoreactive to nNOS or with NADPH-diaphorase activity throughout the subcortical compartment. Neurons immunoreactive to nNOS were observed in the nucleus accumbens, associating NO with mechanisms of addiction and reward; in the nuclei of the amygdala and in the hippocampus, that are associated with learning and memory; in the bed nucleus of the stria terminalis, associated to defense behaviors, analgesia and cardiovascular functions; and in the basal nuclei, suggesting a putative neuroprotector role and neural regulation of the movement, being still associated with neurodegenerative diseases in these regions. The distribution of NO in the subcortical telencephalon of rock cavy is broad, heterogeneous and complex, which can mean a broad role of NO in the cerebral functions of this species. In addition, the mapping of nNOS distribution is being important for the morphological definition of the rock cavy's brain areas in comparison with other species of rodents and other mammals.

MEMBROS DA BANCA:
Externo à Instituição - JOSÉ RODOLFO LOPES DE PAIVA CAVALCANTI - UERN
Presidente - 3550124 - JUDNEY CLEY CAVALCANTE
Interno - 7346484 - MIRIAM STELA MARIS DE OLIVEIRA COSTA