Banca de DEFESA: FLADJANY EMANUELLY FAUSTINO DA SILVA

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
DISCENTE : FLADJANY EMANUELLY FAUSTINO DA SILVA
DATA : 05/08/2016
HORA: 14:00
LOCAL: Auditório do Departamento de Morfologia
TÍTULO:

The effect of the intracerebroventricular injection of Neuropeptide S on the Fos expression in the nuclei of the fear circuitry of Swiss mice

PALAVRAS-CHAVES:

Neuropeptide S; conditioned fear; unconditioned fear; amygdala; hypothalamus

PÁGINAS: 48
GRANDE ÁREA: Ciências Biológicas
ÁREA: Morfologia
SUBÁREA: Anatomia
RESUMO:

Fear and anxiety are emotions featured by a group of physiological and behavioral changes that occur when subjects feel threatened physically and/or psychologically. For the last 2 decades many studies have showed that different sources of fear are able to activate different neural pathways, where conditioned (learned) and unconditioned (innate) fear run over different trails. The conditioned fear involves the frontal medial cortex and the central and basolateral nuclei of the amygdala, when the fear of predator (unconditioned) involves the medial nucleus of the amygdala and the nuclei of the medial hypothalamus. It is known that the brain functions are coordinated by neurotransmitter's systems and its receptors that are expressed in many different places around the brain, having different functions. The Neuropeptide S (NPS) is a neurotransmitter whose studies have showed its important role as an anxiety and awake regulator. NPS decreases anxiety and increases awakeness and locomotor behavior, been thus an anxiolytic and stimulatory neurotransmitter, what makes it a potential target for pharmacological and clinical studies. In the present work we injected NPS in the lateral ventricle (icv) of mice and looked for the Fos-expressing neurons in the nuclei of the conditioned and unconditioned fear pathways. The analysis of our results showed that the icv NPS promoted the increase in Fos expression in the central and basolateral amygdala, nuclei modulating the conditioned fear, but not in the medial nucleus of the amygdala, anterior hypothalamic nucleus, ventromedial nucleus of the hypothalamus and the dorsal premammilary nucleus, nuclei modulating the unconditioned fear, what indicate a major role of the NPS in the conditioned fear.  

MEMBROS DA BANCA:
Externo ao Programa - 2351800 - JEFERSON DE SOUZA CAVALCANTE
Externo à Instituição - JOSÉ RODOLFO LOPES DE PAIVA CAVALCANTI - UERN
Presidente - 3550124 - JUDNEY CLEY CAVALCANTE