Banca de QUALIFICAÇÃO: EPIFANIO FERNANDES DA SILVA
Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.DISCENTE : EPIFANIO FERNANDES DA SILVA
DATA : 15/06/2016
HORA: 08:30
LOCAL: Auditório do Departamento de Morfologia
TÍTULO:
Effect of nociceptin/orphanin FQ receptor ligands on aggressive behavior in male mice
PALAVRAS-CHAVES:
aggressiveness, mouse, nociceptin/orphanin FQ, NOP receptor, resident-intruder test, Ro 65-6570, AT-090, SB-612111.
PÁGINAS: 44
GRANDE ÁREA: Ciências Biológicas
ÁREA: Farmacologia
SUBÁREA: Neuropsicofarmacologia
RESUMO:
INTRODUCTION: Aggression is a behavior shown by several species, including humans. However, violence and impulsivity related to aggressiveness represent a social problem. Indeed, they can be considered symptoms of many psychiatric disorders. Some of the brain areas related to aggressiveness include amygdala, hypothalamus, and prefrontal cortex. Besides, aggressiveness is mediated by different neurotransmitters, such as serotonin, dopamine, noradrenalin, and GABA. These systems represent the therapeutic targets available to treat aggressiveness. The nociceptin/orphanin FQ (N/OFQ) is a heptadecapeptide acting as endogenous ligand of NOP receptor. Clinical and preclinical findings suggest the involvement of N/OFQ – NOP receptor system with psychiatric disorders, including those related to aggressiveness. AIM: This study investigated the effects of standard drugs as well as a NOP receptor ligand on aggressiveness in mice submitted to resident-intruder test. METHODS: Male Swiss mice were used. Valproate 300 mg/kg, Lithium 50 mg/kg, Carbamazepine 20 mg/kg, and Diazepam 1 mg/kg were used as standard ligands. The Ro 65-6570 (0.01 – 1 mg/kg) was used as a NOP agonist. In the resident-intruder test, male mice were housed individually for 7 days (residents) before the experiment. The aggressiveness of each resident mouse was tested twice by inserting an intruder mouse in the resident cage for 10 min. At 8th day of experiment, the resident was tested with no treatment and its basal aggressiveness was recorded; at 11th day, the same mouse was re-tested after being treated. Open field was used to evaluated locomotor activity of mice. RESULTS: Valproate, Lithium, and Carbamazepine reduced the aggressiveness in resident-intruder test. The Ro 65-6560, at doses of 0.03 and 1 mg/kg, increased aggressiveness, and it did not change locomotor activity. The mice treat with Valproate showed a tendency to hyperlocomotion. Lithium, Carbamazepine, and Diazepam did not change locomotor activity. PERSPECTIVES: The partial agonist, AT-090, and the antagonist, SB-612111, of NOP receptor will be evaluated in resident-intruder test and in open field. Diazepam, an anxiolytic drug, will be evaluated in resident-intruder test.
MEMBROS DA BANCA:
Presidente - 1645202 - ELAINE CRISTINA GAVIOLI
Externo ao Programa - 003.367.070-61 - RAMÓN HYPOLITO LIMA - UFRN
Interno - 1720860 - VANESSA DE PAULA SOARES RACHETTI