Multi-objective Optimization of Beam Angle and Fluence Map for IMRT Radiation Therapy
Optimization, Multi-criteria, Radiotherapy
The Beam Angle Optimization (BAO) and the Fluency Map Optimization (FMO) are two problems that arise from the planning of radiation therapy for cancer treatments. One of the main modes of radiation therapy is the IMRT (Intensity Modulated Radiation Therapy) which consists in using computer-controlled linear accelerators to deliver precise radiation doses to the tumor. The IMRT aims at finding a balance between exposing the region of the tumor and, at the same time, preventing, as much as possible, healthy tissues that surround the tumor to receive radiation. This study presents linear and quadratic programming models for the FMO and single and multiobjective algorithms that use those models for the BAO problem. This study also reports the results of computational experiments on a set of real instances.