Banca de QUALIFICAÇÃO: ANTONIO FELIPE LOPES CAVALCANTE

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : ANTONIO FELIPE LOPES CAVALCANTE
DATE: 22/09/2023
TIME: 14:00
LOCAL: REMOTA - https://meet.google.com/mxj-csbw-jkk
TITLE:

TEN SESSIONS OF ANODAL TDCS OVER MOTOR CORTEX IMPROVES PAIN IN CHRONIC CHIKUNGUNYA ARTHRITIS: A RANDOMIZED CONTROLLED TRIAL.

KEY WORDS:

Neuromodulation, chronic pain, arbovirus, non-invasive brain stimulation.

PAGES: 14
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Background: Chikungunya virus (CHIKV) is a globally prevalent pathogen that causes outbreaks in tropical regions. Chronic pain is the main symptom reported and is associated with decreased mobility and disability. Transcranial direct current stimulation (tDCS) emerges as a new therapeutic tool for chronic CHIKV arthralgia.

Objective: This study aimed to evaluate the effect of ten consecutive sessions of anodal tDCS on pain (primary outcome) in patients with chronic CHIKV arthralgia. Secondary outcomes included functional status, quality of life, and mood.

Methods: In this randomized, double-blind, placebo-controlled trial, 30 patients with chronic CHIKV arthralgia were randomly assigned to receive either active (n=15) or sham (n=15) tDCS. The active group received ten consecutive sessions of tDCS over the M1 using the C3/Fp2 montage (2 mA for 20 min). Visual Analog Scale of Pain (VAS), Health Assessment

Questionnaire (HAQ), Short-Form 36 Health Survey (SF-36), Pain Catastrophizing Scale, Hamilton Anxiety Scale (HAS), timed up and go (TUG) test, lumbar dynamometry, 30-s arm curl, and 2-min step test were assessed at baseline, day 10 and in two follow-ups.

Results: It was found a significant interaction between the group and time on pain (p=0.03) with a significant time interaction (p=0.0001). A trend toward the interaction between time and group was found for HAQ (p=0.06). The 2-minute step test does not show significant interaction between time and group (0.18), but the groups significantly differ on day 10 (p=0.01), first follow-up (p=0.01), and second follow-up (p=0.03). There was an improvement in SF-36 but no significant difference could be demonstrated. There was no significant improvement in mental health and physical tests.

Conclusion: tDCS may be a promising intervention for reducing pain in patients with chronic CHIKV arthralgia. However, further research is needed to confirm these findings and explore potential long-term benefits.

COMMITTEE MEMBERS:
Interno - 2646619 - RODRIGO PEGADO DE ABREU FREITAS
Externa ao Programa - 2613606 - SANDRA CRISTINA DE ANDRADE - nullExterna ao Programa - 2319151 - TATIANA SOUZA RIBEIRO - null