Banca de QUALIFICAÇÃO: IASMIN MATIAS SOUSA

Uma banca de QUALIFICAÇÃO de DOUTORADO foi cadastrada pelo programa.
STUDENT : IASMIN MATIAS SOUSA
DATE: 29/05/2023
TIME: 09:00
LOCAL: REMOTA - https://meet.google.com/guu-emto-ybv
TITLE:

INDEPENDENT AND JOINT ASSOCIATION OF SARCOPENIA AND FRAILTY WITH MORTALITY IN OLDER PATIENTS WITH GASTROINTESTINAL CANCER: A COHORT STUDY WITH PROSPECTIVE DATA COLLECTION

KEY WORDS:

muscle mass, handgrip strength, gait speed, adverse outcome, weight loss, oncology.

PAGES: 19
BIG AREA: Ciências da Saúde
AREA: Nutrição
SUMMARY:

Background: Sarcopenia and frailty are associated with mortality in older patients with gastrointestinal cancer. However, it is unclear if there is an additional risk when both are present. This study investigated the independent and overlapping of sarcopenia and frailty with mortality in this population. Methods: A prospective cohort study including older patients with gastrointestinal cancer. Sarcopenia was defined by the EWGSP2 criteria: i) low muscle strength (handgrip test); ii) low muscle mass (skeletal muscle index) and/or low muscle quality (skeletal muscle radiodensity) by computed tomography. Frailty was defined according to Fried phenotype (at least three of the five components): i) low muscle strength (handgrip test); ii) unintentional weight loss; iii) self-reported exhaustion; iv) low physical activity; v) low gait speed. Cox proportional-hazards model were used to assess overall survival rates and risk of mortality. Results: We evaluated 179 patients with gastrointestinal cancer [68.0 (61.0-75.0) years; 45% women]. The prevalence of sarcopenia, frailty, and sarcopenia-frailty was 32.9% (n=59), 59.2% (n=106), and 24.6% (n=44), respectively. The incidence of death was 27.9% (n=50) over a 23-month (IQR:10, 28) period. There was an association of sarcopenia (HR=1.78, 95% CI 1.03-3.06) with mortality, but no association was found of frailty and the outcome. Sarcopenia-frailty was associated with the highest risk of mortality (HR = 2.23, 95% CI 1.27-3.92). Conclusion: Sarcopenic-frail older patients with gastrointestinal cancer have a higher risk of mortality than those with sarcopenia or frailty alone, which reinforces the importance of assessing both conditions in oncology clinical care.

COMMITTEE MEMBERS:
Externo à Instituição - ALEXANDRE COELHO SERQUIZ - UFPB
Presidente - 1879430 - ANA PAULA TRUSSARDI FAYH
Externa ao Programa - ***.670.060-** - FLÁVIA MORAES SILVA - UFCSPA
Externa à Instituição - Gabriela Villaça Chaves - INCA