Banca de DEFESA: RAYSA VANESSA DE MEDEIROS FREITAS

Uma banca de DEFESA de DOUTORADO foi cadastrada pelo programa.
STUDENT : RAYSA VANESSA DE MEDEIROS FREITAS
DATE: 24/05/2023
TIME: 14:00
LOCAL: REMOTA - https://meet.google.com/oew-uykx-yrf
TITLE:

Biomarkers and screening and identification of osteosarcopenia in elderly women using infrared spectroscopy

KEY WORDS:

Analytic chemistry, Chemistry techniques, Osteoporosis, Sarcopenia

PAGES: 126
BIG AREA: Ciências da Saúde
AREA: Fisioterapia e Terapia Ocupacional
SUMMARY:

Osteosarcopenia is a complex geriatric syndrome characterized by the presence of both sarcopenia and osteopenia/osteoporosis. This condition increases rates of disability, falls, fractures, mortality, and mobility impairments in older adults. The purpose of this study was to analyze the Fourier-transform infrared (FTIR) spectroscopy diagnostic power for osteosarcopenia in community-dwelling older women (n = 64; 32 osteosarcopenic and 32 non-osteosarcopenia). FTIR is a fast and reproducible technique highly sensitive to biological tissues, and a mathematical model was created using multivariate classification techniques that denoted the graphic spectra of the molecular groups. Genetic algorithm and support vector machine regression (GA–SVM) was the most feasible model, achieving 80.0% of accuracy. GA–SVM identified 15 wave numbers responsible for class differentiation, in which several amino acids (responsible for the proper activation of the mammalian target of rapamycin) and hydroxyapatite (an inorganic bone component) were observed. Imaging tests and low availability of instruments that allow the observation of osteosarcopenia involve high health costs for patients and restrictive indications. Therefore, FTIR can be used to diagnose osteosarcopenia due to its efficiency and low cost and to enable early detection in geriatric services, contributing to advances in science and technology that are potential “conventional” methods in the future.

COMMITTEE MEMBERS:
Externa à Instituição - DANIELE SIRINEU PEREIRA - UFMG
Interno - 2682821 - EDUARDO CALDAS COSTA
Externo à Instituição - LEOMIR AIRES SILVA DE LIMA - Estácio
Presidente - 350637 - RICARDO OLIVEIRA GUERRA
Interno - 2646619 - RODRIGO PEGADO DE ABREU FREITAS